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US · CSTL

Castle Biosciences, Inc.

Programmatic access: InvestorsCraft Valuation API · catalog

Sector
Healthcare · Medical - Diagnostics & Research
Headquarters
Friendswood, TX 77546

Price · as of 2025

$32.91

Market cap 978.5M

Valuation

MetricValueUpside
IC Value$104.05+216%
P/E-30.67
P/B1.57
P/S2.15
EV/EBITDA42.17
PEG
P/TBV2.00

Valuation history

Annual price overlaid with each model's fair value. Y-axis is log scale.

Annual price and model valuations for CSTL, USD per share
YearPriceAIICGraham-DoddGraham Formula
2011
2012
2013
2014
2015
2016
2017
2018
2019$32.19$240.46
2020$64.19$46.73
2021$39.95$102.29
2022$19.47$15.38
2023$20.79$33.55
2024$20.21$347.95
2025$25.56$34.36

Historic valuation ratios

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USD millions

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        About Castle Biosciences, Inc.

        Castle Biosciences, Inc. functions as a commercial-stage diagnostics firm, with its primary objective being the provision of both diagnostic and prognostic testing services, specifically targeting various dermatological cancers. Their flagship product, DecisionDx-Melanoma, represents an advanced multi-gene expression profile (GEP) assay engineered to assess the probability of metastasis in patients afflicted with invasive cutaneous melanoma. In addition to their leading solution, the company has created several other specialized, proprietary tests. Among these is DecisionDx-UM, a GEP test tailored to forecast the risk of metastasis for individuals with uveal melanoma, a less common malignancy of the eye. Another key offering is DecisionDx-SCC, a distinctive 40-gene expression profile test that utilizes a patient's unique tumor biology to predict their specific risk of squamous cell carcinoma metastasis, particularly for those presenting with recognized risk factors. Moreover, they offer DecisionDx DiffDx-Melanoma and myPath Melanoma, both proprietary GEP tests employed to assist in the accurate diagnosis of ambiguous pigmented lesions. These specialized testing services are provided by Castle Biosciences to patients predominantly through their healthcare providers. The organization commenced operations in 2007 and maintains its corporate headquarters in Friendswood, Texas.

        CEO
        Derek J. Maetzold
        Employees
        883
        Beta
        1.00

        Peer comparison

        Same-industry comparables, ranked by market cap.

        Scroll horizontally for additional metrics. Ticker column stays fixed.

        Peer comparison for CSTL: basic info, valuation models, ratios, profitability, leverage, growth, cash flow, dividends, enterprise value, and Altman Z-score.
        Basic InfoIC ValuationCore ValuationProfitabilityLeverage & LiquidityGrowthCash FlowDividendsEnterprise ValueRisk
        TickerCompany NamePriceMarket CapValueUpsideP/EP/BP/SEV/EBITDAPEGP/TBVGross MarginOperating MarginNet MarginROEROICROADebt/EquityInterest CoverageCurrent RatioQuick RatioNet Debt/EBITDAEPS GrowthSales GrowthFCF GrowthFCF YieldOp Cash Flow RatioCash ROICDividend YieldDividend PayoutShareholder YieldEV/EBITEV/FCFEV/SalesAltman Z-Score
        CSTLCastle Biosciences, Inc.$32.91978.5M$34.36+4%-30.671.572.1542.172.0079.37%-12.44%-7.02%-5.21%-17.64%-4.35%0.08-497.795.264.99-7.04-233.87%3.66%-22.48%3.82%0.9414.26%0.00%0.00%0.00%-11.1716.891.394.54
        AMNAMN Healthcare Services, …$32.801.27B$40.83+24%-7.611.130.2714.81-1.8328.35%1.21%-3.51%-14.19%1.96%-4.24%1.250.730.940.827.61-35.58%-8.49%-2.38%32.12%0.4714.59%0.00%0.00%43.95%45.146.400.552.45
        CDNACareDx, Inc$45.502.35B$32.22-29%-42.452.992.39-162.283.9367.55%-6.60%-5.62%-6.27%-16.81%-4.72%0.092.862.458.43-143.01%13.79%14.43%3.98%0.4724.22%0.00%0.00%9.68%-30.1320.911.993.65
        DRIODarioHealth Corp.$7.6656.01M$14.96+95%-10.716.5819.98-13.03-82.1756.64%-163.94%-186.56%-59.62%-49.81%-36.44%0.47-10.913.733.10-0.16-267.57%-17.31%-32.60%-5.84%-2.78-35.45%0.00%0.00%0.00%-12.34-17.3420.22-0.01
        EMBCEmbecta Corp.$3.57211.8M$27.10+659%7.02-1.030.626.3633.60-0.9962.89%30.48%8.83%-13.73%39.87%8.03%-2.203.072.411.434.0920.90%-3.80%816.58%27.23%0.7331.55%5.23%36.70%26.39%5.6910.281.742.05
        EVHEvolent Health, Inc.$3.08346.44M$8.01+160%-0.590.820.18-3.26-0.11-0.4015.14%-0.24%-28.49%-81.81%-0.32%-26.08%2.38-0.081.311.23-2.32525.93%-26.56%-177.59%1.39%0.100.34%3.26%-1.90%14.97%-265.91248.020.630.23
        FLGTFulgent Genetics, Inc.$18.53526.26M$145.89+687%-7.380.411.41-2.75-18.570.4840.56%-28.23%-18.75%-5.49%-9.62%-5.07%0.01-1214.616.485.030.9339.72%13.83%545.09%-27.32%-1.20-14.90%0.00%0.00%3.06%-1.39-1.020.393.64
        GERNGeron Corporation$1.631.05B$20.93+1,184%-12.284.665.73-18.204.6697.42%-29.28%-46.65%-33.89%-95.18%-14.74%1.11-1.654.663.58-3.32-51.85%138.83%-49.34%-10.55%-1.00-196.41%0.00%0.00%0.00%-17.56-8.515.14-1.85
        MYGNMyriad Genetics, Inc.$3.15297.51M$15.52+393%-1.191.180.53-1.50-0.662.6769.93%-8.22%-44.38%-68.45%-10.76%-42.20%0.57-6.462.491.98-0.18180.85%-1.56%-33.33%-5.89%0.01-4.39%0.00%0.00%0.00%-7.30-19.340.60-0.27
        PSNLPersonalis, Inc.$13.521.44B$12.46-8%-7.382.308.61-5.632.3022.65%-126.43%-116.69%-35.02%-142.75%-26.89%0.15-429.556.766.461.19-33.58%-17.69%69.94%-13.25%-1.89-128.79%0.00%0.00%6.19%-4.54-5.035.742.44
        VIRVir Biotechnology, Inc.$9.111.54B$11.06+21%-2.931.6818.71-2.361.7382.92%-682.68%-638.87%-45.73%-112.47%-36.47%0.245.545.030.11-17.49%-7.61%-12.57%-30.92%-4.22-95.31%0.00%0.00%0.00%-2.15-2.5414.690.60

        Disclaimer: Information on this page is provided for educational purposes only and does not constitute investment advice. Upside computed as ($104.05 ÷ $32.91) − 1 = +216.17% (IC, example).