| Valuation method | Value, $ | Upside, % |
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| Artificial intelligence (AI) | n/a | n/a |
| Intrinsic value (DCF) | n/a | |
| Graham-Dodd Method | n/a | |
| Graham Formula | n/a |
Acrivon Therapeutics, Inc. (NASDAQ: ACRV) is a clinical-stage biopharmaceutical company pioneering precision oncology therapies through its proprietary proteomics-based platform, Acrivon Predictive Precision Proteomics (AP3). Focused on developing targeted treatments for cancer patients, Acrivon leverages its AP3 platform to create companion diagnostics that identify patients most likely to respond to its drug candidates. The company’s lead candidate, ACR-368, is a CHK1/CHK2 inhibitor in a registrational Phase 2 trial for platinum-resistant ovarian, endometrial, and bladder cancers. Additionally, Acrivon is advancing preclinical programs targeting DNA damage response pathways, including WEE1 and PKMYT1 inhibitors. Headquartered in Watertown, Massachusetts, Acrivon combines cutting-edge proteomics with drug development to deliver personalized cancer therapies, positioning itself at the forefront of precision medicine in oncology.
Acrivon Therapeutics presents a high-risk, high-reward investment opportunity in the precision oncology space. The company’s proprietary AP3 platform differentiates it by enabling patient-specific drug response prediction, potentially improving clinical trial success rates. However, as a pre-revenue biotech, Acrivon faces significant cash burn (-$80.6M net income in FY2023) and relies on clinical milestones for value creation. The Phase 2 trial of ACR-368 is a key catalyst, but failure could severely impact valuation. With $39.8M in cash and high beta (1.898), the stock is volatile and suited for speculative investors comfortable with biotech development risks.
Acrivon’s competitive edge lies in its AP3 platform, which integrates proteomics and AI to develop companion diagnostics alongside therapeutics—a differentiated approach in precision oncology. While many biotechs focus on genomics, Acrivon’s proteomic profiling may better predict drug response, reducing trial failure risk. However, the company faces intense competition from established players like AstraZeneca and Merck in DNA damage response inhibitors. ACR-368’s success hinges on demonstrating superior efficacy or safety over PARP inhibitors and other targeted therapies. Acrivon’s preclinical WEE1/PKMYT1 programs compete with emerging candidates from biotechs like Zentalis Pharmaceuticals. The company’s small size limits commercialization capabilities, necessitating partnerships for late-stage development and commercialization. Its niche focus on proteomics-based diagnostics could attract Big Pharma collaboration but also leaves it vulnerable to platform-specific risks.