| Valuation method | Value, $ | Upside, % |
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| Artificial intelligence (AI) | n/a | n/a |
| Intrinsic value (DCF) | n/a | |
| Graham-Dodd Method | n/a | |
| Graham Formula | n/a |
Atossa Therapeutics, Inc. (NASDAQ: ATOS) is a clinical-stage biopharmaceutical company pioneering innovative treatments in oncology and infectious diseases. Headquartered in Seattle, Washington, Atossa focuses on developing novel therapeutics, with its lead candidate, Endoxifen, in Phase II trials for breast cancer treatment and prevention. The company is also advancing AT-H201, an inhalation therapy for severe COVID-19 patients, and AT-301, a nasal-administered COVID-19 treatment. Collaborations with institutions like Dana-Farber Cancer Institute highlight Atossa's commitment to cutting-edge research, particularly in breast cancer immunotherapy. With a market cap of approximately $107 million and a strong cash position, Atossa is positioned to advance its pipeline, though it remains pre-revenue. Investors should note its high-risk, high-reward profile typical of clinical-stage biotech firms.
Atossa Therapeutics presents a speculative investment opportunity with significant upside potential tied to its clinical pipeline, particularly Endoxifen for breast cancer. The company's $71 million cash reserve provides a runway for near-term development, but its lack of revenue and consistent net losses (-$25.5M in latest reporting) underscore high risk. A beta of 1.017 indicates market-correlated volatility. Success in Phase II trials could drive valuation leaps, but failure would likely severely impact the stock. The COVID-19 program diversifies risk but faces stiff competition in a crowded therapeutic space. Suitable only for risk-tolerant investors comfortable with binary clinical trial outcomes.
Atossa competes in the high-stakes oncology and infectious disease markets, where its primary advantage lies in its focused pipeline and intellectual property around Endoxifen—a tamoxifen metabolite potentially offering improved efficacy/safety for breast cancer. Unlike many biotechs pursuing immuno-oncology, Atossa's small-molecule approach may enable faster development and lower production costs. However, it lacks the commercial infrastructure of larger peers, creating dependency on partnerships for late-stage trials and commercialization. In COVID-19 therapeutics, its nasal and inhaled candidates face entrenched competitors like Gilead's remdesivir. The company's $0 debt strengthens its bargaining position for collaborations but its micro-cap size limits R&D scale versus giants like Pfizer or Roche. Atossa's niche positioning in breast cancer prevention could carve a defensible market segment if clinical data proves superior to standard tamoxifen.