Valuation method | Value, $ | Upside, % |
---|---|---|
Artificial intelligence (AI) | 120.51 | 2514 |
Intrinsic value (DCF) | 0.18 | -96 |
Graham-Dodd Method | 13.50 | 193 |
Graham Formula | 49.66 | 977 |
Precision BioSciences, Inc. (NASDAQ: DTIL) is a clinical-stage biotechnology company pioneering next-generation gene editing and allogeneic CAR T-cell therapies. Leveraging its proprietary ARCUS genome editing platform, Precision BioSciences develops precision genetic medicines targeting genetic disorders and cancers. The company's pipeline includes investigational therapies such as PBCAR0191 (for relapsed/refractory non-Hodgkin lymphoma and B-cell acute lymphoblastic leukemia) and PBCAR269A (for multiple myeloma), both in Phase 1/2a trials. Precision BioSciences has strategic collaborations with industry leaders like Servier, Tiziana Life Sciences, and iECURE to expand its therapeutic applications. Headquartered in Durham, North Carolina, the company operates in the high-growth gene editing and immuno-oncology sectors, positioning itself at the forefront of innovative treatments for unmet medical needs.
Precision BioSciences presents a high-risk, high-reward investment opportunity in the gene editing and CAR T-cell therapy space. The company's ARCUS platform offers potential advantages in precision and versatility, supported by early-stage clinical data and strategic partnerships. However, as a clinical-stage biotech, it faces significant risks including trial failures, regulatory hurdles, and cash burn (negative operating cash flow of -$58.4M in the last period). With a market cap of ~$50.8M and $85.9M in cash, investors should monitor clinical milestones and partnership developments closely. The lack of revenue-generating products and dependence on dilutive financing are key concerns, offset by the transformative potential of its pipeline.
Precision BioSciences competes in the crowded gene editing and allogeneic CAR T-cell therapy markets, where it differentiates through its ARCUS platform. ARCUS is a nuclease-based system derived from a natural enzyme, claimed to offer high specificity and smaller size compared to CRISPR/Cas9 systems, potentially enabling more efficient delivery. The company's focus on off-the-shelf (allogeneic) CAR T therapies addresses a key limitation of autologous CAR T treatments (like those from Gilead and Novartis) by enabling scalable manufacturing. However, Precision lags behind CRISPR Therapeutics (CRSP) and Editas Medicine (EDIT) in clinical development breadth. Its partnerships with Servier and others provide validation but also create dependency. The company's modest cash position ($85.9M) may limit its ability to independently advance multiple programs compared to better-funded peers. Success hinges on demonstrating clinical efficacy with PBCAR0191 and other candidates while navigating intellectual property disputes common in gene editing.