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Stock Analysis & ValuationPrecision BioSciences, Inc. (DTIL)

Previous Close
$4.61
Sector Valuation Confidence Level
High
Valuation methodValue, $Upside, %
Artificial intelligence (AI)120.512514
Intrinsic value (DCF)0.18-96
Graham-Dodd Method13.50193
Graham Formula49.66977
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Strategic Investment Analysis

Company Overview

Precision BioSciences, Inc. (NASDAQ: DTIL) is a clinical-stage biotechnology company pioneering next-generation gene editing and allogeneic CAR T-cell therapies. Leveraging its proprietary ARCUS genome editing platform, Precision BioSciences develops precision genetic medicines targeting genetic disorders and cancers. The company's pipeline includes investigational therapies such as PBCAR0191 (for relapsed/refractory non-Hodgkin lymphoma and B-cell acute lymphoblastic leukemia) and PBCAR269A (for multiple myeloma), both in Phase 1/2a trials. Precision BioSciences has strategic collaborations with industry leaders like Servier, Tiziana Life Sciences, and iECURE to expand its therapeutic applications. Headquartered in Durham, North Carolina, the company operates in the high-growth gene editing and immuno-oncology sectors, positioning itself at the forefront of innovative treatments for unmet medical needs.

Investment Summary

Precision BioSciences presents a high-risk, high-reward investment opportunity in the gene editing and CAR T-cell therapy space. The company's ARCUS platform offers potential advantages in precision and versatility, supported by early-stage clinical data and strategic partnerships. However, as a clinical-stage biotech, it faces significant risks including trial failures, regulatory hurdles, and cash burn (negative operating cash flow of -$58.4M in the last period). With a market cap of ~$50.8M and $85.9M in cash, investors should monitor clinical milestones and partnership developments closely. The lack of revenue-generating products and dependence on dilutive financing are key concerns, offset by the transformative potential of its pipeline.

Competitive Analysis

Precision BioSciences competes in the crowded gene editing and allogeneic CAR T-cell therapy markets, where it differentiates through its ARCUS platform. ARCUS is a nuclease-based system derived from a natural enzyme, claimed to offer high specificity and smaller size compared to CRISPR/Cas9 systems, potentially enabling more efficient delivery. The company's focus on off-the-shelf (allogeneic) CAR T therapies addresses a key limitation of autologous CAR T treatments (like those from Gilead and Novartis) by enabling scalable manufacturing. However, Precision lags behind CRISPR Therapeutics (CRSP) and Editas Medicine (EDIT) in clinical development breadth. Its partnerships with Servier and others provide validation but also create dependency. The company's modest cash position ($85.9M) may limit its ability to independently advance multiple programs compared to better-funded peers. Success hinges on demonstrating clinical efficacy with PBCAR0191 and other candidates while navigating intellectual property disputes common in gene editing.

Major Competitors

  • CRISPR Therapeutics AG (CRSP): CRISPR Therapeutics is a leader in CRISPR/Cas9 gene editing with advanced programs including CTX001 (for beta-thalassemia/sickle cell disease) in partnership with Vertex. Its broader pipeline and stronger financial position ($1.8B market cap) give it an edge over Precision, though its technology differs from ARCUS. Weakness includes high valuation multiples and CRISPR patent uncertainties.
  • Editas Medicine, Inc. (EDIT): Editas focuses on CRISPR-based therapies with programs like EDIT-101 (for Leber congenital amaurosis). Its intellectual property position (Broad Institute licenses) is a strength, but clinical progress has been slower than some peers. Compared to Precision, Editas has more cash reserves but less focus on CAR T applications.
  • Intellia Therapeutics, Inc. (NTLA): Intellia is advancing CRISPR/Cas9 therapies for genetic diseases and oncology, with notable in vivo programs like NTLA-2001 for ATTR amyloidosis. Its partnership with Regeneron provides financial stability. Intellia's broader platform approach contrasts with Precision's narrower ARCUS focus, but both face similar delivery challenges.
  • Allogene Therapeutics, Inc. (ALLO): Allogene is a pure-play allogeneic CAR T company with a pipeline targeting CD19, BCMA, and other antigens. Its technology (licensed from Cellectis) is more mature than Precision's CAR T programs, but lacks gene editing capabilities. Allogene's larger market cap ($330M) reflects more advanced clinical assets.
  • Beam Therapeutics Inc. (BEAM): Beam focuses on base editing, a more precise but complex alternative to ARCUS and CRISPR. Its pipeline includes sickle cell disease and alpha-1 antitrypsin deficiency programs. Beam's technology may offer superior precision but with slower development timelines compared to Precision's nuclease approach.
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