Valuation method | Value, $ | Upside, % |
---|---|---|
Artificial intelligence (AI) | 209.75 | -74 |
Intrinsic value (DCF) | 1395.64 | 76 |
Graham-Dodd Method | n/a | |
Graham Formula | 455.52 | -43 |
Eli Lilly and Company (NYSE: LLY) is a global pharmaceutical leader with a 148-year legacy in discovering, developing, and commercializing innovative medicines. Headquartered in Indianapolis, Indiana, Lilly operates in the high-growth Drug Manufacturers - General industry, focusing on diabetes, oncology, immunology, neuroscience, and COVID-19 therapeutics. The company’s blockbuster drugs include Trulicity (type 2 diabetes), Verzenio (breast cancer), Taltz (psoriasis/arthritis), and Mounjaro (a promising GLP-1 receptor agonist for diabetes/obesity). Lilly’s diversified portfolio spans biologics and small molecules, supported by strategic collaborations with biotech firms like Incyte and AbCellera. With a $676 billion market cap (as of latest data), Lilly combines strong R&D (notably in incretin therapies) with global commercialization capabilities. Its diabetes franchise (40% of 2023 revenue) and oncology pipeline position it at the forefront of two of healthcare’s fastest-growing sectors. The company maintains robust cash flows ($8.8B operating cash flow in 2023) to fund both dividends ($6/share) and breakthrough research in Alzheimer’s (donanemab) and obesity (tirzepatide).
Eli Lilly presents a compelling growth investment anchored by its leading diabetes/obesity franchise (Mounjaro/Zepbound) and oncology pipeline, offset by pipeline execution risks and patent expirations (e.g., Trulicity in 2027). The stock trades at a premium (P/E ~58x) reflecting high expectations for tirzepatide’s obesity market potential ($50B+ peak sales estimate). Near-term catalysts include FDA decisions on donanemab (Alzheimer’s) and mirikizumab (ulcerative colitis). Balance sheet strength ($3.3B cash vs $33.6B debt) supports business development, though competitive pressures in GLP-1/GIP drugs (vs Novo Nordisk) and oncology (vs Merck) require monitoring. Dividend yield is modest (0.7%) as capital prioritizes growth initiatives.
Lilly’s competitive advantage stems from: (1) First-mover leadership in GLP-1/GIP therapies (Trulicity, Mounjaro) with superior efficacy in obesity/type 2 diabetes, creating high switching costs; (2) Oncology moats with Verzenio (CDK4/6 inhibitor) and RET inhibitor Retevmo in niche cancers; (3) Vertical integration in insulin production ensuring supply chain resilience. However, Novo Nordisk’s Ozempic/Wegovy dominate the obesity market with earlier approvals, while Merck’s Keytruda remains unmatched in immuno-oncology. Lilly mitigates these threats through tirzepatide’s superior weight loss efficacy (~15-22% vs Wegovy’s ~15%) and diversified pipeline (13 Phase 3 assets in 2024). Pricing power is evidenced by 10%+ annual net price increases for Trulicity, though Medicare price negotiations (2026) pose risks. The company outspends peers in R&D (25% of revenue vs industry 18%), particularly in neurodegenerative diseases where donanemab could challenge Biogen’s Leqembi. Manufacturing scalability gives Lilly an edge in meeting obesity drug demand shortages affecting competitors.