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Altimmune, Inc. (ALT)

Previous Close
$4.26
Sector Valuation Confidence Level
High
Valuation methodValue, $Upside, %
Artificial intelligence (AI)72.341598
Intrinsic value (DCF)0.16-96
Graham-Dodd Methodn/a
Graham Formula111.282512

Strategic Investment Analysis

Company Overview

Altimmune, Inc. (NASDAQ: ALT) is a clinical-stage biopharmaceutical company pioneering innovative treatments for obesity and liver diseases. Headquartered in Gaithersburg, Maryland, Altimmune is advancing pemvidutide (ALT-801), a promising GLP-1/glucagon dual receptor agonist currently in Phase 1b trials for obesity and non-alcoholic steatohepatitis (NASH). The company is also developing HepTcell, an immunotherapeutic candidate in Phase 2 trials for chronic hepatitis B virus (HBV) infection. Operating in the high-growth biotechnology sector, Altimmune leverages its expertise in metabolic and liver disease therapeutics to address unmet medical needs. With a market cap of approximately $463 million, the company is positioned in the competitive obesity and NASH drug development landscape, where demand for novel therapies is surging due to rising global prevalence of these conditions. Altimmune's pipeline targets multi-billion-dollar market opportunities, making it a compelling player in the biotech space.

Investment Summary

Altimmune presents a high-risk, high-reward investment opportunity given its clinical-stage status and focus on large, underserved markets like obesity and NASH. The company's lead candidate, pemvidutide, could differentiate itself in the crowded GLP-1 market through its dual agonist mechanism. However, with no approved products and negative earnings (-$95M net income in latest period), Altimmune remains highly speculative. Its $36.9M cash position may necessitate additional financing. Success hinges on clinical trial outcomes, particularly pemvidutide's efficacy/safety profile versus established players like Novo Nordisk and Eli Lilly. Investors should monitor Phase 1b data readouts and partnership potential. The stock's high beta (1.115) reflects significant volatility risk.

Competitive Analysis

Altimmune competes in two challenging therapeutic areas: obesity (dominated by GLP-1 agonists) and liver diseases (NASH/HBV). Its competitive edge lies in pemvidutide's dual GLP-1/glucagon mechanism, which may offer metabolic advantages over pure GLP-1 drugs like semaglutide by potentially enhancing weight loss and liver benefits. However, the obesity space is increasingly crowded with next-generation therapies from large pharma, requiring Altimmune to demonstrate superior efficacy or tolerability. In NASH, pemvidutide faces competition from Madrigal's resmetirom (first FDA-approved NASH drug) and other late-stage candidates. For HBV, HepTcell's immunotherapeutic approach competes with antiviral therapies and vaccines. Altimmune's small size (vs. big pharma competitors) limits resources but allows agility in clinical development. The company's valuation reflects its early-stage pipeline rather than commercial traction. Success will depend on achieving meaningful differentiation in clinical outcomes and securing strategic partnerships to fund later-stage trials.

Major Competitors

  • Novo Nordisk A/S (NVO): Market leader in obesity with semaglutide (Wegovy) and liraglutide (Saxenda). Strengths include massive commercial infrastructure and proven GLP-1 efficacy. Weakness is single-mechanism focus versus Altimmune's dual agonist approach. Novo's resources dwarf Altimmune's.
  • Eli Lilly and Company (LLY): Dominant with tirzepatide (Zepbound/Mounjaro), a GIP/GLP-1 dual agonist. Strengths include superior weight loss efficacy in trials and strong diabetes franchise. Like Novo, Lilly's scale and commercial capabilities far exceed Altimmune's. Both companies are advancing next-generation obesity candidates.
  • Madrigal Pharmaceuticals, Inc. (MDGL): First mover in NASH with FDA-approved resmetirom (Rezdiffra). Strengths include first-to-market advantage in NASH. Weakness is liver-specific focus without obesity benefits that pemvidutide may offer. Madrigal's commercial infrastructure is more established than Altimmune's.
  • Viking Therapeutics, Inc. (VKTX): Developing VK2735, a dual GLP-1/GIP agonist for obesity/NASH. Similar-stage competitor to Altimmune with promising Phase 2 obesity data. Strengths include clean safety profile. Like Altimmune, lacks commercial capabilities and faces big pharma competition.
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