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Amarin Corporation plc (AMRN)

Previous Close
$16.93
Sector Valuation Confidence Level
High
Valuation methodValue, $Upside, %
Artificial intelligence (AI)52.40210
Intrinsic value (DCF)0.20-99
Graham-Dodd Method0.18-99
Graham Formula3.27-81

Strategic Investment Analysis

Company Overview

Amarin Corporation plc (NASDAQ: AMRN) is a biopharmaceutical company specializing in cardiovascular therapeutics, with its flagship product VASCEPA leading its portfolio. VASCEPA, an FDA-approved omega-3 fatty acid therapy, is prescribed to reduce triglyceride levels in adults with severe hypertriglyceridemia. Headquartered in Dublin, Ireland, Amarin operates primarily in the U.S., Germany, Canada, Lebanon, and the UAE, distributing its products through wholesalers and specialty pharmacies. The company collaborates with Mochida Pharmaceutical Co., Ltd. to expand VASCEPA’s applications. Despite facing generic competition, Amarin remains a key player in the cardiovascular drug market, leveraging its proprietary formulation of icosapent ethyl (EPA). With a focus on underserved cardiovascular conditions, Amarin aims to strengthen its market position through clinical differentiation and strategic partnerships.

Investment Summary

Amarin presents a high-risk, high-reward investment case due to its reliance on VASCEPA, which faces increasing generic competition. The company’s revenue ($228.6M in FY 2023) is under pressure, and net losses (-$82.2M) persist. However, its strong cash position ($121M) and manageable debt ($7.7M) provide some financial flexibility. The stock’s low beta (0.668) suggests relative stability, but growth hinges on expanding VASCEPA’s label and international sales. Investors should weigh the potential for market expansion against competitive threats and litigation risks.

Competitive Analysis

Amarin’s competitive advantage lies in VASCEPA’s unique EPA formulation, which has demonstrated cardiovascular benefits beyond triglyceride reduction in clinical trials. Unlike traditional omega-3 products, VASCEPA is highly purified and FDA-approved for specific high-risk patient groups. However, the loss of patent exclusivity in 2020 exposed it to generic competition, eroding pricing power. Amarin’s strategy focuses on defending its market share through physician education and payer contracts, but rivals like AstraZeneca’s Epanova (discontinued) and other omega-3 generics pose challenges. The company’s collaboration with Mochida in Japan offers growth potential, but execution risks remain. Amarin’s small size limits its R&D capacity compared to larger pharma peers, making it reliant on VASCEPA’s lifecycle management.

Major Competitors

  • AstraZeneca plc (AZN): AstraZeneca’s cardiovascular portfolio includes Crestor (statins) and Farxiga (SGLT2 inhibitor), but its omega-3 drug Epanova was discontinued in 2019 due to trial failures. AZN’s vast resources and global reach overshadow Amarin, though it lacks a direct VASCEPA competitor.
  • Galapagos NV (GLPG): Galapagos focuses on inflammatory and metabolic diseases but does not compete directly with Amarin. Its pipeline lacks cardiovascular assets, making it an indirect competitor at best.
  • Durect Corporation (DRRX): Durect’s Posimir (post-surgical pain) and other candidates do not overlap with VASCEPA’s market. Limited competitive threat.
  • Hikma, Teva, etc. (Generic Manufacturers): Multiple generics have launched EPA-based alternatives to VASCEPA, pressuring Amarin’s pricing and market share. Their low-cost offerings are a significant headwind.
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