Valuation method | Value, $ | Upside, % |
---|---|---|
Artificial intelligence (AI) | 1012.98 | 10875 |
Intrinsic value (DCF) | 0.00 | -100 |
Graham-Dodd Method | n/a | |
Graham Formula | n/a |
Atara Biotherapeutics, Inc. (NASDAQ: ATRA) is a pioneering off-the-shelf T-cell immunotherapy company focused on developing transformative treatments for cancer, autoimmune diseases, and viral infections. Headquartered in South San Francisco, California, Atara leverages its proprietary allogeneic T-cell platform to create therapies that target high-need conditions such as Epstein-Barr virus (EBV)-driven post-transplant lymphoproliferative disease (EBV+ PTLD), nasopharyngeal carcinoma, and multiple sclerosis. The company’s lead candidate, tabelecleucel, is in Phase 3 trials for EBV+ PTLD and has shown promise in hematologic and solid tumors. Atara also advances next-gen CAR T therapies, including ATA2271 and ATA3271 (mesothelin-targeted) and ATA188 (for MS), through strategic collaborations with institutions like Memorial Sloan Kettering and Bayer AG. Operating in the high-growth biotechnology sector, Atara combines innovative science with partnerships to address unmet medical needs, positioning itself as a key player in cell therapy.
Atara Biotherapeutics presents a high-risk, high-reward opportunity for investors focused on cutting-edge immunotherapy. The company’s lead asset, tabelecleucel, could address a niche but critical market in EBV+ PTLD, with potential expansion into larger oncology indications. However, Atara’s financials reflect the challenges of clinical-stage biotech: significant cash burn (-$68.7M operating cash flow in FY2023), negative EPS (-$11.41), and reliance on partnerships for funding. The $43.8M debt load against $25M cash raises liquidity concerns, though its modest $48.5M market cap may appeal to speculative investors betting on clinical successes. Key catalysts include Phase 3 data for tabelecleucel and progress in CAR T programs. Competition from autologous CAR T leaders (e.g., Gilead, Novartis) and allogeneic rivals (e.g., Allogene Therapeutics) adds complexity.
Atara Biotherapeutics differentiates itself through its allogeneic (off-the-shelf) T-cell platform, which offers logistical advantages over autologous CAR T therapies that require patient-specific manufacturing. Its lead candidate, tabelecleucel, targets EBV+ PTLD—a rare but underserved indication with limited competition. While autologous CAR T leaders like Gilead (Yescarta) and Novartis (Kymriah) dominate in hematologic malignancies, Atara’s allogeneic approach could reduce costs and treatment delays. However, the company faces stiff competition in broader oncology from Allogene Therapeutics (ALLO), which also develops allogeneic CAR Ts, and CRISPR Therapeutics (CRSP), advancing gene-edited therapies. Atara’s collaboration with Bayer provides validation but also ties its mesothelin programs to a partner’s priorities. In multiple sclerosis, ATA188 competes with approved anti-CD20 therapies (e.g., Roche’s Ocrevus). Atara’s niche focus on EBV+ diseases provides short-term differentiation, but long-term success hinges on expanding into larger markets where scalability and manufacturing efficiency will be critical against deep-pocketed rivals.