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Coherus BioSciences, Inc. (CHRS)

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$0.88
Sector Valuation Confidence Level
High
Valuation methodValue, $Upside, %
Artificial intelligence (AI)77.778738
Intrinsic value (DCF)0.00-100
Graham-Dodd Method0.09-90
Graham Formula2.93233

Strategic Investment Analysis

Company Overview

Coherus BioSciences, Inc. (NASDAQ: CHRS) is a leading biopharmaceutical company specializing in biosimilars and immuno-oncology therapies, primarily serving the U.S. market. Headquartered in Redwood City, California, Coherus is known for its flagship product, UDENYCA, a biosimilar to Neulasta, which supports cancer patients by stimulating white blood cell production. The company’s robust pipeline includes biosimilars for blockbuster drugs like Humira, Avastin, and Lucentis, positioning it as a key player in the cost-effective biosimilar market. Additionally, Coherus is advancing Toripalimab, an anti-PD-1 antibody for melanoma treatment in China, through partnerships with Innovent Biologics and Junshi Biosciences. With strategic collaborations with industry giants like AbbVie and Pfizer, Coherus leverages cutting-edge biotechnology to expand access to affordable biologics. Operating in the high-growth biotechnology sector, Coherus addresses critical healthcare needs in oncology and autoimmune diseases, making it a compelling investment in the evolving biosimilar landscape.

Investment Summary

Coherus BioSciences presents a high-risk, high-reward opportunity in the biosimilar and immuno-oncology space. The company’s revenue is anchored by UDENYCA, but its future hinges on pipeline execution, particularly its Humira biosimilar (launching in 2023) and Toripalimab’s expansion. While the biosimilar market offers growth potential due to cost pressures in healthcare, Coherus faces stiff competition from entrenched players like Amgen and Pfizer. Financials show modest profitability (net income of $28.5M in FY2023), but operating cash flow remains negative (-$20.4M), reflecting R&D and commercialization costs. With $126M in cash and $270M in debt, liquidity is manageable but requires careful monitoring. Investors should weigh the upside of successful biosimilar launches against regulatory risks and pricing pressures in the sector.

Competitive Analysis

Coherus BioSciences competes in the biosimilar and immuno-oncology markets, where differentiation hinges on regulatory approvals, manufacturing efficiency, and commercialization partnerships. Its primary competitive advantage lies in its focused biosimilar portfolio, including first-to-market products like UDENYCA and a high-potential Humira biosimilar. The company’s partnership with Junshi Biosciences for Toripalimab provides a foothold in China’s growing immuno-oncology market. However, Coherus faces intense competition from larger biopharma firms with deeper pipelines and stronger commercialization capabilities, such as Amgen (Neulasta originator) and Biocon (strong biosimilar presence). Pricing pressure from U.S. healthcare reforms and payer negotiations further complicates margin sustainability. Coherus mitigates these risks through strategic alliances (e.g., with Pfizer) and a lean operational model. Its ability to secure formulary placements for UDENYCA and upcoming launches will be critical to maintaining market share against rivals like Sandoz (Novartis) and Celltrion.

Major Competitors

  • Amgen Inc. (AMGN): Amgen dominates the originator biologics market (e.g., Neulasta) and has a strong biosimilar division. Its scale and established sales infrastructure pose a challenge to Coherus, though Amgen’s focus on higher-margin originators limits aggressive biosimilar pricing.
  • Pfizer Inc. (PFE): Pfizer’s biosimilar portfolio (e.g., Retacrit) and global reach make it a formidable competitor. However, its partnership with Coherus for UDENYCA distribution creates a dual dynamic of competition and collaboration.
  • Novartis AG (Sandoz) (NVS): Sandoz, Novartis’ generics unit, is a biosimilar leader with products like Zarxio (Neupogen biosimilar). Its extensive pipeline and European stronghold contrast with Coherus’ U.S.-centric strategy.
  • Regeneron Pharmaceuticals (REGN): Regeneron’s focus on innovative biologics (e.g., Eylea) places it in indirect competition with Coherus’ Lucentis biosimilar. Its R&D prowess and pricing power in ophthalmology could pressure Coherus’ market entry.
  • Biogen Inc. (BIIB): Biogen’s biosimilar ventures (e.g., Imraldi, a Humira biosimilar in Europe) compete with Coherus’ pipeline. However, Biogen’s recent strategic shifts away from biosimilars may reduce direct rivalry.
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