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US · SYRE

Spyre Therapeutics, Inc.

Programmatic access: InvestorsCraft Valuation API · catalog

Sector
Healthcare · Biotechnology
Headquarters
Waltham, MA 02453
Website
spyre.com

Price · as of 2026-09-04

$88.98

Market cap 9.06B

Price history

Weekly OHLC price history for SYRE, USD per share
WeekOpenHighLowCloseVolume
Apr 4, 2016 – Apr 8, 2016$250.00$318.75$240.25$299.750
Apr 11, 2016 – Apr 15, 2016$296.75$301.00$235.50$249.000
Apr 18, 2016 – Apr 22, 2016$251.75$252.00$209.00$229.750
Apr 25, 2016 – Apr 29, 2016$235.25$256.25$213.75$219.000
May 2, 2016 – May 6, 2016$224.75$251.25$214.25$217.750
May 9, 2016 – May 13, 2016$218.00$231.25$167.00$179.250
May 16, 2016 – May 20, 2016$183.50$212.50$170.25$186.500
May 23, 2016 – May 27, 2016$186.75$206.00$171.25$181.000
May 30, 2016 – Jun 3, 2016$181.25$192.50$171.25$190.000
Jun 6, 2016 – Jun 10, 2016$190.00$190.38$146.25$157.000
Jun 13, 2016 – Jun 17, 2016$155.25$163.50$109.75$111.500
Jun 20, 2016 – Jun 24, 2016$115.25$135.50$102.50$134.000
Jun 27, 2016 – Jul 1, 2016$134.00$149.50$116.25$121.250
Jul 4, 2016 – Jul 8, 2016$123.25$123.25$97.25$105.250
Jul 11, 2016 – Jul 15, 2016$107.45$122.00$101.25$113.000
Jul 18, 2016 – Jul 22, 2016$117.65$118.72$106.25$116.250
Jul 25, 2016 – Jul 29, 2016$117.50$126.18$112.00$120.000
Aug 1, 2016 – Aug 5, 2016$118.75$123.25$112.50$117.250
Aug 8, 2016 – Aug 12, 2016$116.75$122.25$113.75$115.000
Aug 15, 2016 – Aug 19, 2016$117.15$150.00$112.50$129.000
Aug 22, 2016 – Aug 26, 2016$131.25$149.00$125.53$147.380
Aug 29, 2016 – Sep 2, 2016$145.25$159.25$137.00$156.250
Sep 5, 2016 – Sep 9, 2016$157.50$188.50$157.25$173.750
Sep 12, 2016 – Sep 16, 2016$172.00$207.50$172.00$192.750
Sep 19, 2016 – Sep 23, 2016$192.75$193.75$152.75$162.250
Sep 26, 2016 – Sep 30, 2016$164.50$186.00$160.25$160.250
Oct 3, 2016 – Oct 7, 2016$162.25$184.23$158.90$171.000
Oct 10, 2016 – Oct 14, 2016$165.00$180.20$161.75$168.750
Oct 17, 2016 – Oct 21, 2016$171.98$174.50$153.25$156.750
Oct 24, 2016 – Oct 28, 2016$162.00$169.50$131.50$145.000
Oct 31, 2016 – Nov 4, 2016$145.27$158.63$133.00$153.000
Nov 7, 2016 – Nov 11, 2016$152.75$152.75$137.52$148.250
Nov 14, 2016 – Nov 18, 2016$150.00$163.25$141.50$145.750
Nov 21, 2016 – Nov 25, 2016$147.50$258.50$122.50$127.250
Nov 28, 2016 – Dec 2, 2016$130.00$145.25$125.00$142.500
Dec 5, 2016 – Dec 9, 2016$141.25$156.75$128.65$138.000
Dec 12, 2016 – Dec 16, 2016$137.00$147.50$128.50$135.000
Dec 19, 2016 – Dec 23, 2016$136.00$137.80$119.00$127.500
Dec 26, 2016 – Dec 30, 2016$126.25$131.25$106.75$108.750
Jan 2, 2017 – Jan 6, 2017$109.00$135.00$109.00$131.500
Jan 9, 2017 – Jan 13, 2017$127.75$134.75$125.25$129.750
Jan 16, 2017 – Jan 20, 2017$131.25$132.38$115.00$115.250
Jan 23, 2017 – Jan 27, 2017$118.50$125.00$100.00$100.500
Jan 30, 2017 – Feb 3, 2017$101.50$109.82$91.50$100.500
Feb 6, 2017 – Feb 10, 2017$102.75$121.18$101.25$117.750
Feb 13, 2017 – Feb 17, 2017$118.75$138.75$115.25$130.500
Feb 20, 2017 – Feb 24, 2017$130.50$157.07$129.00$145.750
Feb 27, 2017 – Mar 3, 2017$149.00$160.98$141.25$153.250
Mar 6, 2017 – Mar 10, 2017$154.50$171.90$142.00$163.250
Mar 13, 2017 – Mar 17, 2017$162.00$199.75$160.75$193.500
Mar 20, 2017 – Mar 24, 2017$192.25$203.50$171.50$184.250
Mar 27, 2017 – Mar 31, 2017$176.50$191.25$169.00$186.250
Apr 3, 2017 – Apr 7, 2017$187.50$190.50$163.85$181.250
Apr 10, 2017 – Apr 13, 2017$181.50$188.80$163.45$186.000
Apr 17, 2017 – Apr 21, 2017$187.50$193.50$167.75$176.000
Apr 24, 2017 – Apr 28, 2017$175.75$183.75$170.50$178.750
May 1, 2017 – May 5, 2017$177.85$182.05$162.75$162.750
May 8, 2017 – May 12, 2017$162.50$167.25$148.75$157.500
May 15, 2017 – May 19, 2017$157.50$163.40$152.00$162.000
May 22, 2017 – May 26, 2017$162.00$168.50$106.50$112.500
May 29, 2017 – Jun 2, 2017$110.40$112.78$102.25$104.500
Jun 5, 2017 – Jun 9, 2017$105.25$110.75$88.00$89.250
Jun 12, 2017 – Jun 16, 2017$90.00$92.25$82.00$87.500
Jun 19, 2017 – Jun 23, 2017$87.50$101.07$84.50$89.500
Jun 26, 2017 – Jun 30, 2017$90.25$100.00$90.25$96.250
Jul 3, 2017 – Jul 7, 2017$94.82$97.75$82.75$84.750
Jul 10, 2017 – Jul 14, 2017$85.00$98.50$82.50$94.750
Jul 17, 2017 – Jul 21, 2017$95.00$97.25$84.25$92.500
Jul 24, 2017 – Jul 28, 2017$88.75$96.25$81.50$83.250
Jul 31, 2017 – Aug 4, 2017$83.75$90.75$77.75$81.250
Aug 7, 2017 – Aug 11, 2017$81.75$83.50$70.25$72.750
Aug 14, 2017 – Aug 18, 2017$72.75$78.25$70.25$74.250
Aug 21, 2017 – Aug 25, 2017$75.00$82.00$73.50$82.000
Aug 28, 2017 – Sep 1, 2017$81.25$119.00$80.00$102.250
Sep 4, 2017 – Sep 8, 2017$101.50$122.50$100.00$107.500
Sep 11, 2017 – Sep 15, 2017$110.50$120.00$101.32$120.000
Sep 18, 2017 – Sep 22, 2017$118.75$128.00$109.85$121.500
Sep 25, 2017 – Sep 29, 2017$121.25$124.75$113.25$123.250
Oct 2, 2017 – Oct 6, 2017$126.50$136.23$116.50$133.380
Oct 9, 2017 – Oct 13, 2017$133.50$156.00$119.75$128.250
Oct 16, 2017 – Oct 20, 2017$140.00$148.10$120.50$126.250
Oct 23, 2017 – Oct 27, 2017$124.00$125.25$107.00$109.500
Oct 30, 2017 – Nov 3, 2017$109.35$125.25$103.50$123.250
Nov 6, 2017 – Nov 10, 2017$122.50$131.50$112.50$128.250
Nov 13, 2017 – Nov 17, 2017$127.75$130.00$110.50$113.500
Nov 20, 2017 – Nov 24, 2017$115.25$118.75$103.50$106.750
Nov 27, 2017 – Dec 1, 2017$105.50$124.50$93.75$118.250
Dec 4, 2017 – Dec 8, 2017$122.25$129.50$114.25$128.500
Dec 11, 2017 – Dec 15, 2017$129.75$142.50$119.25$121.750
Dec 18, 2017 – Dec 22, 2017$122.50$131.88$121.50$129.500
Dec 25, 2017 – Dec 29, 2017$129.50$147.00$128.25$135.250
Jan 1, 2018 – Jan 5, 2018$136.00$147.00$126.25$138.000
Jan 8, 2018 – Jan 12, 2018$139.25$168.50$123.75$156.500
Jan 15, 2018 – Jan 19, 2018$158.75$172.00$147.50$168.750
Jan 22, 2018 – Jan 26, 2018$170.00$191.75$153.85$168.250
Jan 29, 2018 – Feb 2, 2018$167.48$180.25$145.50$164.750
Feb 5, 2018 – Feb 9, 2018$161.50$173.75$128.00$136.250
Feb 12, 2018 – Feb 16, 2018$140.00$164.75$140.00$152.000
Feb 19, 2018 – Feb 23, 2018$158.75$162.25$146.75$157.250
Feb 26, 2018 – Mar 2, 2018$159.75$186.40$157.00$181.000
Mar 5, 2018 – Mar 9, 2018$181.00$232.25$170.02$220.750
Mar 12, 2018 – Mar 16, 2018$219.25$274.25$199.50$266.000
Mar 19, 2018 – Mar 23, 2018$265.25$283.75$251.52$259.250
Mar 26, 2018 – Mar 29, 2018$270.75$270.75$215.70$248.000
Apr 2, 2018 – Apr 6, 2018$251.25$268.20$218.75$223.000
Apr 9, 2018 – Apr 13, 2018$225.00$263.23$195.75$240.500
Apr 16, 2018 – Apr 20, 2018$240.75$247.25$187.50$196.750
Apr 23, 2018 – Apr 27, 2018$197.75$229.25$193.30$221.000
Apr 30, 2018 – May 4, 2018$220.00$256.25$220.00$243.750
May 7, 2018 – May 11, 2018$244.50$262.50$241.23$248.500
May 14, 2018 – May 18, 2018$248.00$279.75$239.73$264.250
May 21, 2018 – May 25, 2018$263.25$273.50$233.25$265.500
May 28, 2018 – Jun 1, 2018$265.00$300.00$246.00$249.750
Jun 4, 2018 – Jun 8, 2018$248.75$265.50$226.75$262.750
Jun 11, 2018 – Jun 15, 2018$262.50$275.00$234.57$264.750
Jun 18, 2018 – Jun 22, 2018$262.50$283.00$251.25$268.000
Jun 25, 2018 – Jun 29, 2018$268.25$276.75$255.25$264.500
Jul 2, 2018 – Jul 6, 2018$264.50$284.25$247.50$254.250
Jul 9, 2018 – Jul 13, 2018$254.75$266.00$217.50$219.500
Jul 16, 2018 – Jul 20, 2018$221.25$237.75$219.88$230.000
Jul 23, 2018 – Jul 27, 2018$228.50$241.25$209.25$213.750
Jul 30, 2018 – Aug 3, 2018$215.25$234.75$206.00$223.250
Aug 6, 2018 – Aug 10, 2018$222.25$243.75$215.95$237.000
Aug 13, 2018 – Aug 17, 2018$236.25$245.50$219.70$230.000
Aug 20, 2018 – Aug 24, 2018$234.25$261.25$223.75$257.000
Aug 27, 2018 – Aug 31, 2018$258.75$279.00$254.77$273.250
Sep 3, 2018 – Sep 7, 2018$277.75$277.75$203.00$218.500
Sep 10, 2018 – Sep 14, 2018$218.50$224.50$201.25$212.750
Sep 17, 2018 – Sep 21, 2018$213.50$230.50$207.50$229.000
Sep 24, 2018 – Sep 28, 2018$226.75$241.00$212.50$239.250
Oct 1, 2018 – Oct 5, 2018$247.75$262.25$225.00$244.750
Oct 8, 2018 – Oct 12, 2018$244.75$248.25$214.75$227.000
Oct 15, 2018 – Oct 19, 2018$226.50$257.00$223.50$232.500
Oct 22, 2018 – Oct 26, 2018$236.00$237.38$210.00$215.000
Oct 29, 2018 – Nov 2, 2018$218.00$233.75$203.00$231.750
Nov 5, 2018 – Nov 9, 2018$232.75$241.00$217.77$227.500
Nov 12, 2018 – Nov 16, 2018$224.00$225.75$191.00$207.750
Nov 19, 2018 – Nov 23, 2018$208.00$212.75$186.25$199.750
Nov 26, 2018 – Nov 30, 2018$202.50$218.75$196.25$210.500
Dec 3, 2018 – Dec 7, 2018$213.50$220.50$188.50$196.750
Dec 10, 2018 – Dec 14, 2018$199.00$212.30$185.00$187.500
Dec 17, 2018 – Dec 21, 2018$188.50$198.75$157.75$162.750
Dec 24, 2018 – Dec 28, 2018$161.50$206.50$161.50$191.750
Dec 31, 2018 – Jan 4, 2019$191.00$212.50$178.75$210.500
Jan 7, 2019 – Jan 11, 2019$205.50$219.75$203.50$212.750
Jan 14, 2019 – Jan 18, 2019$212.00$229.25$205.00$223.000
Jan 21, 2019 – Jan 25, 2019$221.25$223.95$206.75$214.000
Jan 28, 2019 – Feb 1, 2019$211.50$233.25$207.50$229.500
Feb 4, 2019 – Feb 8, 2019$226.75$236.25$180.00$195.750
Feb 11, 2019 – Feb 15, 2019$198.00$211.25$187.50$208.750
Feb 18, 2019 – Feb 22, 2019$207.50$210.50$197.50$206.250
Feb 25, 2019 – Mar 1, 2019$207.50$216.75$201.00$214.750
Mar 4, 2019 – Mar 8, 2019$216.50$217.82$196.50$200.000
Mar 11, 2019 – Mar 15, 2019$201.00$211.98$191.75$200.000
Mar 18, 2019 – Mar 22, 2019$201.50$210.75$193.25$193.750
Mar 25, 2019 – Mar 29, 2019$188.50$202.00$188.25$201.250
Apr 1, 2019 – Apr 5, 2019$200.00$223.00$191.25$219.250
Apr 8, 2019 – Apr 12, 2019$221.75$222.50$180.25$181.250
Apr 15, 2019 – Apr 18, 2019$181.00$190.38$173.02$184.250
Apr 22, 2019 – Apr 26, 2019$185.75$189.00$177.07$180.250
Apr 29, 2019 – May 3, 2019$180.00$182.00$161.25$174.000
May 6, 2019 – May 10, 2019$170.50$176.75$165.68$171.250
May 13, 2019 – May 17, 2019$168.75$173.75$160.50$162.000
May 20, 2019 – May 24, 2019$166.00$177.00$159.07$170.500
May 27, 2019 – May 31, 2019$169.25$172.50$153.77$156.000
Jun 3, 2019 – Jun 7, 2019$155.75$166.25$151.13$158.250
Jun 10, 2019 – Jun 14, 2019$158.50$160.00$149.75$154.500
Jun 17, 2019 – Jun 21, 2019$157.00$168.50$156.75$162.750
Jun 24, 2019 – Jun 28, 2019$162.75$174.73$155.00$171.250
Jul 1, 2019 – Jul 5, 2019$172.50$173.75$161.75$164.500
Jul 8, 2019 – Jul 12, 2019$163.75$168.75$158.75$167.250
Jul 15, 2019 – Jul 19, 2019$167.25$179.75$165.25$175.000
Jul 22, 2019 – Jul 26, 2019$175.25$214.50$167.50$209.000
Jul 29, 2019 – Aug 2, 2019$209.25$227.50$206.82$223.500
Aug 5, 2019 – Aug 9, 2019$218.00$218.00$185.00$195.750
Aug 12, 2019 – Aug 16, 2019$194.50$206.00$190.70$197.500
Aug 19, 2019 – Aug 23, 2019$199.25$207.00$182.75$185.250
Aug 26, 2019 – Aug 30, 2019$186.75$196.75$184.75$195.130
Sep 2, 2019 – Sep 6, 2019$193.75$217.50$188.50$200.250
Sep 9, 2019 – Sep 13, 2019$201.25$224.00$195.25$212.500
Sep 16, 2019 – Sep 20, 2019$210.00$220.50$207.00$216.500
Sep 23, 2019 – Sep 27, 2019$212.75$221.00$187.90$191.000
Sep 30, 2019 – Oct 4, 2019$191.75$195.75$178.38$180.750
Oct 7, 2019 – Oct 11, 2019$180.00$198.50$176.25$194.750
Oct 14, 2019 – Oct 18, 2019$192.50$199.73$184.25$195.500
Oct 21, 2019 – Oct 25, 2019$198.75$200.00$181.00$186.250
Oct 28, 2019 – Nov 1, 2019$186.75$207.50$185.00$206.000
Nov 4, 2019 – Nov 8, 2019$204.00$212.50$189.18$198.250
Nov 11, 2019 – Nov 15, 2019$195.00$204.25$191.38$195.750
Nov 18, 2019 – Nov 22, 2019$193.75$213.75$182.00$210.750
Nov 25, 2019 – Nov 29, 2019$213.50$216.75$202.50$213.750
Dec 2, 2019 – Dec 6, 2019$212.50$213.00$192.00$197.000
Dec 9, 2019 – Dec 13, 2019$196.50$209.50$193.25$195.500
Dec 16, 2019 – Dec 20, 2019$199.50$202.38$182.70$183.750
Dec 23, 2019 – Dec 27, 2019$185.50$203.75$180.50$197.500
Dec 30, 2019 – Jan 3, 2020$198.25$200.00$183.25$192.250
Jan 6, 2020 – Jan 10, 2020$189.25$200.25$184.75$191.000
Jan 13, 2020 – Jan 17, 2020$189.50$201.50$185.75$198.500
Jan 20, 2020 – Jan 24, 2020$198.75$201.00$183.25$184.750
Jan 27, 2020 – Jan 31, 2020$182.25$189.00$167.25$181.500
Feb 3, 2020 – Feb 7, 2020$182.50$211.25$176.75$195.750
Feb 10, 2020 – Feb 14, 2020$193.25$212.50$193.25$203.750
Feb 17, 2020 – Feb 21, 2020$205.25$206.25$192.75$196.750
Feb 24, 2020 – Feb 28, 2020$187.50$200.00$163.88$170.750
Mar 2, 2020 – Mar 6, 2020$169.25$176.00$152.00$157.750
Mar 9, 2020 – Mar 13, 2020$150.25$161.00$110.00$120.000
Mar 16, 2020 – Mar 20, 2020$110.00$131.25$87.50$99.750
Mar 23, 2020 – Mar 27, 2020$99.00$130.25$92.50$118.000
Mar 30, 2020 – Apr 3, 2020$119.25$119.50$100.00$100.250
Apr 6, 2020 – Apr 9, 2020$105.75$142.25$105.75$136.000
Apr 13, 2020 – Apr 17, 2020$137.50$154.75$122.75$141.500
Apr 20, 2020 – Apr 24, 2020$139.50$148.50$127.50$141.750
Apr 27, 2020 – May 1, 2020$142.75$199.25$138.00$187.500
May 4, 2020 – May 8, 2020$197.75$218.00$185.25$206.250
May 11, 2020 – May 15, 2020$206.50$215.75$155.00$178.000
May 18, 2020 – May 22, 2020$185.50$225.50$185.50$222.250
May 25, 2020 – May 29, 2020$230.00$234.50$212.00$220.250
Jun 1, 2020 – Jun 5, 2020$219.25$243.25$212.75$231.250
Jun 8, 2020 – Jun 12, 2020$236.25$236.25$187.50$209.750
Jun 15, 2020 – Jun 19, 2020$203.25$273.00$191.00$262.500
Jun 22, 2020 – Jun 26, 2020$265.00$284.50$222.50$230.250
Jun 29, 2020 – Jul 2, 2020$227.75$248.75$223.25$226.500
Jul 6, 2020 – Jul 10, 2020$233.25$233.25$215.75$221.250
Jul 13, 2020 – Jul 17, 2020$223.50$224.50$193.50$198.500
Jul 20, 2020 – Jul 24, 2020$198.00$205.75$173.75$181.000
Jul 27, 2020 – Jul 31, 2020$181.00$185.75$166.25$171.250
Aug 3, 2020 – Aug 7, 2020$171.75$177.50$169.25$174.500
Aug 10, 2020 – Aug 14, 2020$174.25$176.50$160.75$166.250
Aug 17, 2020 – Aug 21, 2020$167.50$178.25$161.00$162.750
Aug 24, 2020 – Aug 28, 2020$164.75$176.75$162.50$175.500
Aug 31, 2020 – Sep 4, 2020$174.50$187.50$172.00$182.500
Sep 7, 2020 – Sep 11, 2020$181.00$185.75$171.25$173.750
Sep 14, 2020 – Sep 18, 2020$175.75$199.00$172.50$197.000
Sep 21, 2020 – Sep 25, 2020$193.50$198.25$165.25$176.500
Sep 28, 2020 – Oct 2, 2020$179.00$196.00$173.75$175.500
Oct 5, 2020 – Oct 9, 2020$176.00$218.25$175.75$197.500
Oct 12, 2020 – Oct 16, 2020$197.75$209.50$189.75$204.000
Oct 19, 2020 – Oct 23, 2020$205.50$207.50$188.75$192.000
Oct 26, 2020 – Oct 30, 2020$186.50$203.25$175.50$192.000
Nov 2, 2020 – Nov 6, 2020$194.00$215.00$181.50$207.000
Nov 9, 2020 – Nov 13, 2020$210.00$247.50$207.13$235.000
Nov 16, 2020 – Nov 20, 2020$241.50$245.00$211.75$215.750
Nov 23, 2020 – Nov 27, 2020$218.50$226.75$211.25$215.250
Nov 30, 2020 – Dec 4, 2020$213.25$227.25$199.75$205.000
Dec 7, 2020 – Dec 11, 2020$205.25$224.00$186.75$213.250
Dec 14, 2020 – Dec 18, 2020$216.00$244.50$211.25$223.500
Dec 21, 2020 – Dec 24, 2020$211.50$223.25$200.00$203.250
Dec 28, 2020 – Dec 31, 2020$204.75$210.13$193.82$196.750
Jan 4, 2021 – Jan 8, 2021$199.00$217.50$191.75$204.500
Jan 11, 2021 – Jan 15, 2021$199.75$208.50$194.50$199.500
Jan 18, 2021 – Jan 22, 2021$201.75$204.00$180.50$190.750
Jan 25, 2021 – Jan 29, 2021$190.50$196.50$164.50$173.750
Feb 1, 2021 – Feb 5, 2021$174.50$197.25$173.75$190.000
Feb 8, 2021 – Feb 12, 2021$193.00$199.50$185.00$190.750
Feb 15, 2021 – Feb 19, 2021$193.75$196.25$174.50$182.250
Feb 22, 2021 – Feb 26, 2021$181.00$191.50$173.75$186.250
Mar 1, 2021 – Mar 5, 2021$186.25$204.25$175.50$181.250
Mar 8, 2021 – Mar 12, 2021$191.00$210.00$186.75$198.750
Mar 15, 2021 – Mar 19, 2021$200.50$202.00$184.25$197.250
Mar 22, 2021 – Mar 26, 2021$206.00$219.75$182.50$191.000
Mar 29, 2021 – Apr 1, 2021$188.75$202.00$176.25$200.750
Apr 5, 2021 – Apr 9, 2021$202.25$216.00$189.25$192.750
Apr 12, 2021 – Apr 16, 2021$191.50$206.25$178.50$204.250
Apr 19, 2021 – Apr 23, 2021$201.50$202.50$180.50$195.500
Apr 26, 2021 – Apr 30, 2021$194.50$217.00$192.00$194.500
May 3, 2021 – May 7, 2021$195.00$201.75$177.25$181.000
May 10, 2021 – May 14, 2021$180.50$193.00$174.00$189.000
May 17, 2021 – May 21, 2021$186.25$195.00$178.50$183.500
May 24, 2021 – May 28, 2021$184.00$184.00$164.25$165.250
May 31, 2021 – Jun 4, 2021$163.75$173.75$159.00$164.250
Jun 7, 2021 – Jun 11, 2021$165.50$176.50$162.00$165.000
Jun 14, 2021 – Jun 18, 2021$166.50$167.00$160.00$161.000
Jun 21, 2021 – Jun 25, 2021$162.00$196.50$153.75$195.750
Jun 28, 2021 – Jul 2, 2021$193.75$193.75$173.25$175.750
Jul 5, 2021 – Jul 9, 2021$176.50$182.50$173.13$178.750
Jul 12, 2021 – Jul 16, 2021$178.25$181.00$169.00$169.250
Jul 19, 2021 – Jul 23, 2021$166.50$174.75$160.00$164.000
Jul 26, 2021 – Jul 30, 2021$165.00$171.50$151.00$153.250
Aug 2, 2021 – Aug 6, 2021$154.00$171.00$152.00$164.000
Aug 9, 2021 – Aug 13, 2021$165.25$165.75$145.50$150.750
Aug 16, 2021 – Aug 20, 2021$150.75$178.50$149.25$175.250
Aug 23, 2021 – Aug 27, 2021$175.00$187.00$167.50$184.000
Aug 30, 2021 – Sep 3, 2021$184.00$187.50$168.50$185.000
Sep 6, 2021 – Sep 10, 2021$185.50$193.75$167.50$170.250
Sep 13, 2021 – Sep 17, 2021$172.00$187.75$168.50$186.750
Sep 20, 2021 – Sep 24, 2021$183.75$201.25$183.75$191.750
Sep 27, 2021 – Oct 1, 2021$193.25$208.00$190.50$205.000
Oct 4, 2021 – Oct 8, 2021$205.00$212.50$193.63$194.500
Oct 11, 2021 – Oct 15, 2021$193.75$212.50$193.00$204.500
Oct 18, 2021 – Oct 22, 2021$203.75$205.00$175.25$182.500
Oct 25, 2021 – Oct 29, 2021$183.00$197.00$178.00$183.000
Nov 1, 2021 – Nov 5, 2021$184.75$198.50$181.75$183.000
Nov 8, 2021 – Nov 12, 2021$184.50$188.50$175.00$176.000
Nov 15, 2021 – Nov 19, 2021$175.25$181.82$162.50$167.000
Nov 22, 2021 – Nov 26, 2021$168.00$177.25$156.00$161.250
Nov 29, 2021 – Dec 3, 2021$164.25$164.25$147.50$150.000
Dec 6, 2021 – Dec 10, 2021$114.00$117.22$86.75$93.000
Dec 13, 2021 – Dec 17, 2021$91.75$103.25$87.25$101.250
Dec 20, 2021 – Dec 23, 2021$97.50$107.50$93.03$105.250
Dec 27, 2021 – Dec 31, 2021$104.50$119.25$100.75$118.750
Jan 3, 2022 – Jan 7, 2022$119.75$120.75$103.75$107.000
Jan 10, 2022 – Jan 14, 2022$105.50$116.00$100.25$113.750
Jan 17, 2022 – Jan 21, 2022$111.75$119.72$104.60$108.000
Jan 24, 2022 – Jan 28, 2022$105.75$112.75$94.50$101.000
Jan 31, 2022 – Feb 4, 2022$101.25$113.50$100.75$106.750
Feb 7, 2022 – Feb 11, 2022$106.25$112.50$85.25$85.750
Feb 14, 2022 – Feb 18, 2022$86.00$88.50$75.75$76.000
Feb 21, 2022 – Feb 25, 2022$75.00$75.25$66.50$71.750
Feb 28, 2022 – Mar 4, 2022$70.50$73.75$56.00$56.250
Mar 7, 2022 – Mar 11, 2022$56.50$62.50$49.50$49.750
Mar 14, 2022 – Mar 18, 2022$49.75$72.75$45.00$68.000
Mar 21, 2022 – Mar 25, 2022$68.00$68.50$58.25$58.500
Mar 28, 2022 – Apr 1, 2022$57.75$66.00$55.25$65.250
Apr 4, 2022 – Apr 8, 2022$65.50$71.00$60.25$65.000
Apr 11, 2022 – Apr 14, 2022$64.00$79.25$46.13$49.500
Apr 18, 2022 – Apr 22, 2022$47.50$50.45$42.00$43.250
Apr 25, 2022 – Apr 29, 2022$42.75$45.00$35.88$36.000
May 2, 2022 – May 6, 2022$35.75$40.75$34.25$34.750
May 9, 2022 – May 13, 2022$34.25$38.75$32.25$34.500
May 16, 2022 – May 20, 2022$33.75$39.75$33.75$37.500
May 23, 2022 – May 27, 2022$37.00$39.65$33.25$39.250
May 30, 2022 – Jun 3, 2022$38.75$41.00$15.00$15.600
Jun 6, 2022 – Jun 10, 2022$15.58$19.75$14.63$17.750
Jun 13, 2022 – Jun 17, 2022$17.75$18.50$16.25$16.250
Jun 20, 2022 – Jun 24, 2022$16.50$16.50$14.55$14.550
Jun 27, 2022 – Jul 1, 2022$14.75$15.00$12.45$12.750
Jul 4, 2022 – Jul 8, 2022$13.00$13.73$12.25$13.080
Jul 11, 2022 – Jul 15, 2022$13.00$13.25$11.33$11.730
Jul 18, 2022 – Jul 22, 2022$11.73$12.38$10.55$10.730
Jul 25, 2022 – Jul 29, 2022$10.93$11.00$10.00$10.380
Aug 1, 2022 – Aug 5, 2022$10.25$10.75$9.30$10.500
Aug 8, 2022 – Aug 12, 2022$11.03$13.00$10.03$12.300
Aug 15, 2022 – Aug 19, 2022$12.50$26.00$11.78$22.750
Aug 22, 2022 – Aug 26, 2022$19.60$19.95$12.50$12.950
Aug 29, 2022 – Sep 2, 2022$13.50$15.25$12.53$13.000
Sep 5, 2022 – Sep 9, 2022$12.63$13.25$12.00$12.250
Sep 12, 2022 – Sep 16, 2022$12.25$13.50$11.53$12.250
Sep 19, 2022 – Sep 23, 2022$12.25$13.13$10.75$11.030
Sep 26, 2022 – Sep 30, 2022$10.75$13.38$10.53$13.150
Oct 3, 2022 – Oct 7, 2022$13.25$14.00$12.50$12.550
Oct 10, 2022 – Oct 14, 2022$12.55$13.20$11.50$12.130
Oct 17, 2022 – Oct 21, 2022$12.35$13.75$11.63$12.730
Oct 24, 2022 – Oct 28, 2022$12.60$28.25$12.00$23.000
Oct 31, 2022 – Nov 4, 2022$21.05$36.75$19.30$27.750
Nov 7, 2022 – Nov 11, 2022$28.50$39.00$27.25$34.250
Nov 14, 2022 – Nov 18, 2022$35.00$35.50$28.25$30.250
Nov 21, 2022 – Nov 25, 2022$29.25$33.13$29.00$31.000
Nov 28, 2022 – Dec 2, 2022$32.75$32.75$9.78$12.500
Dec 5, 2022 – Dec 9, 2022$12.50$12.83$8.90$9.400
Dec 12, 2022 – Dec 16, 2022$9.25$10.25$8.78$9.350
Dec 19, 2022 – Dec 23, 2022$9.50$9.70$8.50$8.980
Dec 26, 2022 – Dec 30, 2022$8.75$11.25$8.53$11.250
Jan 2, 2023 – Jan 6, 2023$10.88$13.50$10.00$12.500
Jan 9, 2023 – Jan 13, 2023$12.70$13.50$12.25$13.250
Jan 16, 2023 – Jan 20, 2023$13.80$15.50$12.10$12.350
Jan 23, 2023 – Jan 27, 2023$12.88$13.00$11.75$12.750
Jan 30, 2023 – Feb 3, 2023$12.25$13.00$11.83$12.600
Feb 6, 2023 – Feb 10, 2023$12.38$14.15$12.25$13.400
Feb 13, 2023 – Feb 17, 2023$13.40$13.40$11.50$12.480
Feb 20, 2023 – Feb 24, 2023$12.28$12.48$8.32$9.800
Feb 27, 2023 – Mar 3, 2023$10.18$11.95$9.25$9.850
Mar 6, 2023 – Mar 10, 2023$9.55$11.20$9.28$9.500
Mar 13, 2023 – Mar 17, 2023$9.25$10.00$7.50$7.800
Mar 20, 2023 – Mar 24, 2023$7.80$8.88$7.50$8.250
Mar 27, 2023 – Mar 31, 2023$8.25$8.25$7.13$7.250
Apr 3, 2023 – Apr 6, 2023$7.43$7.43$6.48$6.480
Apr 10, 2023 – Apr 14, 2023$6.40$6.53$3.63$3.750
Apr 17, 2023 – Apr 21, 2023$3.93$4.38$3.53$4.250
Apr 24, 2023 – Apr 28, 2023$4.43$4.43$3.80$4.220
May 1, 2023 – May 5, 2023$4.25$4.43$3.88$4.000
May 8, 2023 – May 12, 2023$4.20$4.35$3.80$3.830
May 15, 2023 – May 19, 2023$3.80$3.90$3.55$3.650
May 22, 2023 – May 26, 2023$3.65$3.85$3.35$3.380
May 29, 2023 – Jun 2, 2023$3.38$3.68$3.13$3.200
Jun 5, 2023 – Jun 9, 2023$3.38$3.73$2.85$3.350
Jun 12, 2023 – Jun 16, 2023$3.40$4.15$3.25$3.500
Jun 19, 2023 – Jun 23, 2023$3.75$24.00$2.65$10.000
Jun 26, 2023 – Jun 30, 2023$9.90$11.45$8.53$11.280
Jul 3, 2023 – Jul 7, 2023$11.28$13.85$9.53$12.000
Jul 10, 2023 – Jul 14, 2023$11.30$14.10$11.30$13.980
Jul 17, 2023 – Jul 21, 2023$13.83$18.00$13.33$14.830
Jul 24, 2023 – Jul 28, 2023$14.75$15.80$13.25$14.400
Jul 31, 2023 – Aug 4, 2023$14.00$14.50$11.63$12.000
Aug 7, 2023 – Aug 11, 2023$11.68$13.13$10.25$12.500
Aug 14, 2023 – Aug 18, 2023$12.00$12.80$11.00$12.250
Aug 21, 2023 – Aug 25, 2023$12.25$14.50$11.40$13.080
Aug 28, 2023 – Sep 1, 2023$12.80$14.88$12.75$14.500
Sep 4, 2023 – Sep 8, 2023$14.50$16.58$11.75$14.000
Sep 11, 2023 – Sep 15, 2023$13.43$15.63$12.71$13.900
Sep 18, 2023 – Sep 22, 2023$13.60$14.56$10.22$11.860
Sep 25, 2023 – Sep 29, 2023$11.78$12.42$10.65$12.250
Oct 2, 2023 – Oct 6, 2023$12.04$12.25$9.23$11.750
Oct 9, 2023 – Oct 13, 2023$11.61$13.00$10.85$12.980
Oct 16, 2023 – Oct 20, 2023$12.32$15.39$11.78$13.250
Oct 23, 2023 – Oct 27, 2023$13.03$13.39$10.30$10.660
Oct 30, 2023 – Nov 3, 2023$10.76$12.54$10.17$11.310
Nov 6, 2023 – Nov 10, 2023$11.40$11.66$8.43$9.490
Nov 13, 2023 – Nov 17, 2023$9.41$11.92$8.87$10.250
Nov 20, 2023 – Nov 24, 2023$10.00$11.77$8.75$11.040
Nov 27, 2023 – Dec 1, 2023$10.87$21.40$10.42$19.580
Dec 4, 2023 – Dec 8, 2023$19.50$22.66$17.04$19.610
Dec 11, 2023 – Dec 15, 2023$21.29$21.29$14.22$15.500
Dec 18, 2023 – Dec 22, 2023$16.83$18.40$15.37$18.170
Dec 25, 2023 – Dec 29, 2023$18.11$22.00$17.83$21.520
Jan 1, 2024 – Jan 5, 2024$21.99$23.00$18.54$22.240
Jan 8, 2024 – Jan 12, 2024$22.17$25.81$20.32$21.400
Jan 15, 2024 – Jan 19, 2024$21.45$24.81$20.50$24.120
Jan 22, 2024 – Jan 26, 2024$24.31$28.66$24.22$27.500
Jan 29, 2024 – Feb 2, 2024$27.50$28.59$24.56$25.740
Feb 5, 2024 – Feb 9, 2024$25.64$26.08$23.56$23.950
Feb 12, 2024 – Feb 16, 2024$23.67$24.00$21.73$23.220
Feb 19, 2024 – Feb 23, 2024$23.37$23.74$20.07$23.580
Feb 26, 2024 – Mar 1, 2024$23.58$32.99$23.05$29.900
Mar 4, 2024 – Mar 8, 2024$31.39$41.09$30.90$37.930
Mar 11, 2024 – Mar 15, 2024$37.06$47.61$35.93$45.370
Mar 18, 2024 – Mar 22, 2024$47.89$47.97$37.41$41.200
Mar 25, 2024 – Mar 28, 2024$41.20$43.00$36.39$37.930
Apr 1, 2024 – Apr 5, 2024$37.82$39.69$33.57$36.180
Apr 8, 2024 – Apr 12, 2024$36.77$40.84$35.63$37.490
Apr 15, 2024 – Apr 19, 2024$36.53$38.54$31.97$32.410
Apr 22, 2024 – Apr 26, 2024$33.00$35.88$31.27$33.560
Apr 29, 2024 – May 3, 2024$34.03$39.04$31.39$35.780
May 6, 2024 – May 10, 2024$35.97$38.64$31.79$36.930
May 13, 2024 – May 17, 2024$37.22$40.49$36.04$37.800
May 20, 2024 – May 24, 2024$37.52$37.90$32.10$32.980
May 27, 2024 – May 31, 2024$33.53$35.83$31.76$34.950
Jun 3, 2024 – Jun 7, 2024$35.00$37.50$33.05$33.670
Jun 10, 2024 – Jun 14, 2024$33.78$38.90$30.74$31.510
Jun 17, 2024 – Jun 21, 2024$31.62$32.00$23.78$24.100
Jun 24, 2024 – Jun 28, 2024$23.94$24.77$22.19$23.510
Jul 1, 2024 – Jul 5, 2024$23.71$26.18$23.00$25.490
Jul 8, 2024 – Jul 12, 2024$26.86$29.77$25.10$29.680
Jul 15, 2024 – Jul 19, 2024$29.84$32.10$28.45$29.500
Jul 22, 2024 – Jul 26, 2024$30.42$32.41$29.11$31.470
Jul 29, 2024 – Aug 2, 2024$31.05$31.59$25.48$26.190
Aug 5, 2024 – Aug 9, 2024$24.64$26.56$24.32$24.800
Aug 12, 2024 – Aug 16, 2024$24.88$26.62$23.31$26.040
Aug 19, 2024 – Aug 23, 2024$26.03$28.50$24.47$25.530
Aug 26, 2024 – Aug 30, 2024$25.87$29.00$25.15$28.750
Sep 2, 2024 – Sep 6, 2024$28.18$29.12$26.52$27.960
Sep 9, 2024 – Sep 13, 2024$28.37$30.25$27.29$29.360
Sep 16, 2024 – Sep 20, 2024$29.31$31.89$27.09$30.170
Sep 23, 2024 – Sep 27, 2024$29.56$30.52$27.64$28.490
Sep 30, 2024 – Oct 4, 2024$28.39$29.94$26.84$29.150
Oct 7, 2024 – Oct 11, 2024$29.15$29.37$26.28$28.700
Oct 14, 2024 – Oct 18, 2024$28.41$34.14$28.30$32.760
Oct 21, 2024 – Oct 25, 2024$32.67$36.60$31.70$34.810
Oct 28, 2024 – Nov 1, 2024$35.49$36.09$32.22$33.980
Nov 4, 2024 – Nov 8, 2024$33.59$39.63$33.00$39.580
Nov 11, 2024 – Nov 15, 2024$38.85$40.26$29.14$29.200
Nov 18, 2024 – Nov 22, 2024$29.27$30.34$25.74$27.700
Nov 25, 2024 – Nov 29, 2024$28.26$28.55$27.18$28.430
Dec 2, 2024 – Dec 6, 2024$28.40$29.06$25.13$27.080
Dec 9, 2024 – Dec 13, 2024$27.23$27.64$23.50$24.120
Dec 16, 2024 – Dec 20, 2024$23.94$25.67$22.57$23.860
Dec 23, 2024 – Dec 27, 2024$23.74$24.34$22.73$23.670
Dec 30, 2024 – Jan 3, 2025$23.35$24.83$22.37$24.350
Jan 6, 2025 – Jan 10, 2025$24.66$26.01$21.60$22.460
Jan 13, 2025 – Jan 17, 2025$23.00$23.00$20.33$20.620
Jan 20, 2025 – Jan 24, 2025$21.00$22.82$20.97$21.600
Jan 27, 2025 – Jan 31, 2025$21.31$23.59$20.25$22.990
Feb 3, 2025 – Feb 7, 2025$22.04$24.83$21.67$22.650
Feb 10, 2025 – Feb 14, 2025$22.87$23.75$21.13$22.920
Feb 17, 2025 – Feb 21, 2025$23.04$23.60$20.26$21.290
Feb 24, 2025 – Feb 28, 2025$21.48$21.93$18.26$19.700
Mar 3, 2025 – Mar 7, 2025$19.96$21.03$17.24$19.490
Mar 10, 2025 – Mar 14, 2025$18.98$19.74$17.25$18.040
Mar 17, 2025 – Mar 21, 2025$18.07$19.00$17.54$18.170
Mar 24, 2025 – Mar 28, 2025$18.36$19.50$16.71$17.940
Mar 31, 2025 – Apr 4, 2025$17.56$17.68$12.56$12.790
Apr 7, 2025 – Apr 11, 2025$12.00$13.76$10.91$12.220
Apr 14, 2025 – Apr 17, 2025$12.63$13.29$12.04$12.670
Apr 21, 2025 – Apr 25, 2025$12.54$14.99$12.53$14.130
Apr 28, 2025 – May 2, 2025$14.16$15.77$14.16$15.110
May 5, 2025 – May 9, 2025$14.91$15.10$12.29$14.100
May 12, 2025 – May 16, 2025$15.22$15.57$14.12$15.180
May 19, 2025 – May 23, 2025$14.95$15.55$14.59$15.010
May 26, 2025 – May 30, 2025$15.41$15.71$14.75$15.280
Jun 2, 2025 – Jun 6, 2025$15.40$17.57$14.92$16.970
Jun 9, 2025 – Jun 13, 2025$17.40$19.20$16.83$17.290
Jun 16, 2025 – Jun 20, 2025$17.51$18.01$13.93$15.010
Jun 23, 2025 – Jun 27, 2025$14.84$17.29$14.09$15.220
Jun 30, 2025 – Jul 3, 2025$15.27$16.61$14.00$15.760
Jul 7, 2025 – Jul 11, 2025$15.63$16.92$14.97$15.690
Jul 14, 2025 – Jul 18, 2025$15.61$17.18$15.05$16.290
Jul 21, 2025 – Jul 25, 2025$16.39$18.31$16.16$17.790
Jul 28, 2025 – Aug 1, 2025$17.82$18.00$16.23$16.260
Aug 4, 2025 – Aug 8, 2025$16.30$17.01$14.75$15.160
Aug 11, 2025 – Aug 15, 2025$15.11$17.42$14.72$16.950
Aug 18, 2025 – Aug 22, 2025$16.95$17.80$15.73$17.380
Aug 25, 2025 – Aug 29, 2025$17.25$17.46$16.27$16.490
Sep 1, 2025 – Sep 5, 2025$16.26$17.58$16.12$17.000
Sep 8, 2025 – Sep 12, 2025$16.98$17.13$15.64$15.650
Sep 15, 2025 – Sep 19, 2025$15.62$15.84$14.64$14.880
Sep 22, 2025 – Sep 26, 2025$14.86$17.12$14.51$16.240
Sep 29, 2025 – Oct 3, 2025$16.27$17.19$15.49$15.890
Oct 6, 2025 – Oct 10, 2025$16.03$21.51$15.86$19.140
Oct 13, 2025 – Oct 17, 2025$19.15$23.49$18.12$22.470
Oct 20, 2025 – Oct 24, 2025$22.86$24.03$21.88$23.370
Oct 27, 2025 – Oct 31, 2025$24.01$25.06$23.52$24.460
Nov 3, 2025 – Nov 7, 2025$23.95$24.45$21.15$22.520
Nov 10, 2025 – Nov 14, 2025$22.93$24.50$21.63$23.500
Nov 17, 2025 – Nov 21, 2025$23.47$25.42$23.01$24.260
Nov 24, 2025 – Nov 28, 2025$24.95$30.21$24.58$30.000
Dec 1, 2025 – Dec 5, 2025$30.55$34.54$28.16$33.450
Dec 8, 2025 – Dec 12, 2025$33.95$35.31$33.24$33.620
Dec 15, 2025 – Dec 19, 2025$33.93$34.96$32.26$33.400
Dec 22, 2025 – Dec 26, 2025$32.93$34.52$32.30$32.940
Dec 29, 2025 – Jan 2, 2026$32.77$33.31$30.11$30.580
Jan 5, 2026 – Jan 9, 2026$30.49$31.69$28.00$30.610
Jan 12, 2026 – Jan 16, 2026$30.60$34.21$30.00$33.240
Jan 19, 2026 – Jan 23, 2026$32.34$35.07$31.62$32.030
Jan 26, 2026 – Jan 30, 2026$31.52$34.03$31.52$31.980
Feb 2, 2026 – Feb 6, 2026$31.76$35.21$30.92$35.120
Feb 9, 2026 – Feb 13, 2026$35.12$37.98$32.35$36.630
Feb 16, 2026 – Feb 20, 2026$36.39$43.56$34.96$43.210
Feb 23, 2026 – Feb 27, 2026$43.01$45.76$42.03$43.010
Mar 2, 2026 – Mar 6, 2026$41.27$42.93$38.36$40.150
Mar 9, 2026 – Mar 13, 2026$39.75$42.93$39.00$39.890
Mar 16, 2026 – Mar 20, 2026$40.73$45.39$40.73$41.250
Mar 23, 2026 – Mar 27, 2026$42.02$49.31$40.91$47.310
Mar 30, 2026 – Apr 2, 2026$47.75$51.06$44.80$47.580
Apr 6, 2026 – Apr 10, 2026$47.58$54.39$46.79$51.290
Apr 13, 2026 – Apr 17, 2026$67.00$75.00$59.02$73.010
Apr 20, 2026 – Apr 24, 2026$72.20$74.84$68.33$69.670
Apr 27, 2026 – May 1, 2026$69.53$76.00$67.50$69.420
May 4, 2026 – May 8, 2026$68.26$75.91$67.18$75.050
May 11, 2026 – May 15, 2026$75.15$78.80$72.54$74.920
May 18, 2026 – May 22, 2026$75.08$75.65$64.67$74.050
May 25, 2026 – May 29, 2026$74.87$76.12$71.08$73.500
Jun 1, 2026 – Jun 5, 2026$72.39$79.54$68.50$73.650
Jun 8, 2026 – Jun 12, 2026$75.53$84.43$70.89$80.790
Jun 15, 2026 – Jun 18, 2026$81.57$90.99$80.79$88.340
Jun 22, 2026 – Jun 26, 2026$95.00$102.06$81.65$87.890
Jun 29, 2026 – Jul 2, 2026$86.56$91.96$84.81$86.630
Jul 6, 2026 – Jul 10, 2026$87.27$99.34$86.60$97.740
Jul 13, 2026 – Jul 17, 2026$95.72$105.09$92.37$100.230
Jul 20, 2026 – Jul 24, 2026$101.02$103.57$97.00$102.130
Jul 27, 2026 – Jul 31, 2026$102.01$105.05$92.37$98.330
Aug 3, 2026 – Aug 7, 2026$97.15$108.14$92.71$104.910
Aug 10, 2026 – Aug 14, 2026$106.19$107.00$95.61$103.630
Aug 17, 2026 – Aug 21, 2026$102.94$110.18$101.44$106.490
Aug 24, 2026 – Aug 28, 2026$106.49$110.15$89.45$90.360
Aug 31, 2026 – Sep 4, 2026$89.15$90.97$84.00$88.980

Valuation

MetricValueUpside
IC Value
P/E-16.46
P/B3.57
P/S
EV/EBITDA-8.58
PEG
P/TBV3.57

Valuation history

Annual price overlaid with each model's fair value. Y-axis is log scale.

Annual price and model valuations for SYRE, USD per share
YearPriceAIICGraham-DoddGraham Formula
2011
2012
2013
2014
2015
2016$163.25$78.23
2017$220.75
2018$200.00$47.64
2019$157.75
2020$198.75
2021$49.75
2022$9.50$1.90
2023$37.93$7.58
2024$19.49
2025$39.89

Historic valuation ratios

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USD millions

Line items

    USD millions

    Line items

      USD millions

      Line items

        About Spyre Therapeutics, Inc.

        Spyre Therapeutics, Inc. is a biotechnology firm operating at the preclinical stage, dedicated to creating innovative treatments for individuals afflicted with inflammatory bowel disease (IBD). Among its pipeline candidates is SPY001, a human monoclonal immunoglobulin G1 antibody specifically engineered to target and bind with the a4ß7 integrin. This particular therapy is under development for addressing both ulcerative colitis and Crohn's disease, two forms of IBD. Furthermore, Spyre Therapeutics is advancing SPY002, another human monoclonal antibody that aims to interact with tumor necrosis factor-like ligand 1A (TL1A). A synergistic approach is also being explored with SPY120, a compound that merges the anti-a4ß7 action of SPY001 with the anti-TL1A activity of SPY002. All these programs are currently undergoing preclinical evaluation. Beyond these, the company's early-stage portfolio encompasses several additional promising candidates: SPY003, an anti-IL-23 monoclonal antibody; SPY004, a monoclonal antibody with a novel mechanism of action; SPY130, which combines anti-a4ß7 and anti-IL-23 antibodies; and SPY230, a dual antibody therapy featuring anti-TL1A and anti-IL-23 components. Originally incorporated in 2013, the organization was previously known as Aeglea BioTherapeutics, Inc., before rebranding to Spyre Therapeutics, Inc. in November 2023. Its headquarters are located in Waltham, Massachusetts.

        CEO
        Cameron Turtle
        Employees
        102
        Beta
        3.02

        Peer comparison

        Same-industry comparables, ranked by market cap.

        Scroll horizontally for additional metrics. Ticker column stays fixed.

        Peer comparison for SYRE: basic info, valuation models, ratios, profitability, leverage, growth, cash flow, dividends, enterprise value, and Altman Z-score.
        Basic InfoIC ValuationCore ValuationProfitabilityLeverage & LiquidityGrowthCash FlowDividendsEnterprise ValueRisk
        TickerCompany NamePriceMarket CapValueUpsideP/EP/BP/SEV/EBITDAPEGP/TBVGross MarginOperating MarginNet MarginROEROICROADebt/EquityInterest CoverageCurrent RatioQuick RatioNet Debt/EBITDAEPS GrowthSales GrowthFCF GrowthFCF YieldOp Cash Flow RatioCash ROICDividend YieldDividend PayoutShareholder YieldEV/EBITEV/FCFEV/SalesAltman Z-Score
        SYRESpyre Therapeutics, Inc.$104.919.06B-16.463.57-8.583.570.00%0.00%0.00%-25.17%331.08%-22.39%0.0013.2512.890.41-37.74%7.52%-6.62%-2.88267.42%0.00%0.00%0.00%-8.58-10.6322.70
        ABCLAbCellera Biologics Inc.$6.932.12B$20.45+195%-7.121.0813.88-4.381.1861.64%-288.98%-194.88%-14.47%-33.39%-10.78%0.1511.3210.69-0.10-10.91%160.56%-6.89%-16.70%-2.04-32.47%0.00%0.00%0.00%-3.00-3.748.681.69
        ARDXArdelyx, Inc.$4.00988.12M$15.11+278%-22.628.343.42-45.94-42.728.3489.54%-10.06%-15.12%-36.21%-43.02%-13.14%1.27-1.444.313.80-4.9252.94%22.09%-4.03%-3.16%-0.48-46.17%0.00%0.00%0.00%-32.70-30.473.291.10
        CLDXCelldex Therapeutics, Inc…$41.712.78B$15.31-63%-7.583.721308.28-5.66-12.813.93100.00%-19160.00%-17253.33%-40.62%-1576.31%-37.63%0.0010.4910.210.1059.18%-78.63%33.79%-10.89%-4.14-1171.86%0.00%0.00%0.10%-5.03-6.77964.1216.11
        IMNMImmunome, Inc.$25.032.39B$14.77-41%-8.372.80256.23-5.392.8057.43%-3084.76%-3059.99%-52.09%919.14%-46.00%0.0114.6914.533.10-51.40%-23.23%22.09%-11.28%-4.24861.15%0.00%0.00%28.74%-5.27-5.63162.6320.41
        MAZEMaze Therapeutics, Inc.$28.651.59B$7.24-75%-16.466.08-14.296.080.00%0.00%0.00%-47.52%-453.11%-41.12%0.0715.5015.161.29-4020.31%-100.00%-250.70%-5.22%-4.96-357.46%0.00%0.00%0.00%-12.87-16.3128.78
        NTLAIntellia Therapeutics, In…$11.941.34B$9.46-21%-2.662.0620.44-2.592.0676.47%-651.67%-609.85%-67.26%-110.87%-51.06%0.145.084.420.16-27.43%16.92%0.00%-25.65%-3.36-89.17%0.00%0.00%6.01%-2.33-2.8915.17-0.49
        PHVSPharvaris N.V.$34.912.44B-7.494.79-5.83-37.904.790.00%0.00%0.00%-64.45%1070.30%-58.60%0.0010.1110.011.6819.76%13.73%-10.55%-4.63864.94%0.00%0.00%0.85%-5.95-7.3622.38
        UPBUpstream Bio, Inc.$7.25394.54M$9.33+29%-3.471.46174.16-1.09-4.411.46100.00%-5618.82%-5026.03%-35.43%-41869.71%-34.34%0.0026.1525.440.7078.52%20.42%123.58%-26.85%-9.91-34840.73%0.00%0.00%0.00%-0.98-1.1854.9519.64
        WVEWave Life Sciences Ltd.$6.101.2B$15.97+162%-10.744.1751.39-8.24-14.754.1779.28%-504.09%-478.33%-55.56%343.98%-41.26%0.036.476.352.9972.86%-60.55%23.85%-8.57%-1.97300.58%0.00%0.00%14.01%-7.48-8.5637.728.76
        ZYMEZymeworks Inc.$23.541.73B$116.79+396%-21.256.4216.27-22.04-0.13100.00%-87.33%-76.56%-26.72%-97.68%-20.04%0.075.525.520.33-33.33%38.87%-69.48%-2.00%-0.78-36.45%0.00%0.00%2.42%-16.35-43.8314.289.49

        Disclaimer: Information on this page is provided for educational purposes only and does not constitute investment advice. Upside computed as (— ÷ $88.98) − 1 = — (IC, example).