US · UPB
Upstream Bio, Inc.
Price · as of 2026-09-04
$6.01
Market cap 366.79M
Price history
| Week | Open | High | Low | Close | Volume |
|---|---|---|---|---|---|
| Oct 7, 2024 – Oct 11, 2024 | $21.50 | $23.88 | $21.00 | $22.00 | |
| Oct 14, 2024 – Oct 18, 2024 | $21.32 | $26.88 | $20.74 | $25.88 | 0 |
| Oct 21, 2024 – Oct 25, 2024 | $25.99 | $27.68 | $24.59 | $25.06 | 0 |
| Oct 28, 2024 – Nov 1, 2024 | $25.01 | $25.59 | $23.79 | $24.76 | 0 |
| Nov 4, 2024 – Nov 8, 2024 | $24.76 | $29.46 | $24.35 | $26.18 | 0 |
| Nov 11, 2024 – Nov 15, 2024 | $26.42 | $27.87 | $25.24 | $25.46 | 0 |
| Nov 18, 2024 – Nov 22, 2024 | $25.42 | $26.70 | $17.09 | $18.19 | 0 |
| Nov 25, 2024 – Nov 29, 2024 | $18.19 | $22.40 | $18.00 | $21.87 | 0 |
| Dec 2, 2024 – Dec 6, 2024 | $21.70 | $24.28 | $20.92 | $23.84 | 0 |
| Dec 9, 2024 – Dec 13, 2024 | $24.37 | $24.98 | $19.38 | $20.25 | 0 |
| Dec 16, 2024 – Dec 20, 2024 | $19.81 | $20.94 | $14.97 | $16.21 | 0 |
| Dec 23, 2024 – Dec 27, 2024 | $16.07 | $20.17 | $15.91 | $19.19 | 0 |
| Dec 30, 2024 – Jan 3, 2025 | $18.70 | $18.74 | $15.67 | $18.35 | 0 |
| Jan 6, 2025 – Jan 10, 2025 | $18.53 | $18.95 | $13.42 | $13.70 | 0 |
| Jan 13, 2025 – Jan 17, 2025 | $13.35 | $13.37 | $10.36 | $11.00 | 0 |
| Jan 20, 2025 – Jan 24, 2025 | $11.01 | $11.34 | $10.24 | $10.39 | 0 |
| Jan 27, 2025 – Jan 31, 2025 | $10.24 | $11.80 | $9.29 | $10.77 | 0 |
| Feb 3, 2025 – Feb 7, 2025 | $10.42 | $10.65 | $7.70 | $7.92 | 0 |
| Feb 10, 2025 – Feb 14, 2025 | $7.98 | $8.36 | $6.65 | $7.60 | 0 |
| Feb 17, 2025 – Feb 21, 2025 | $7.75 | $8.74 | $7.66 | $7.98 | 0 |
| Feb 24, 2025 – Feb 28, 2025 | $7.96 | $8.39 | $7.33 | $7.93 | 0 |
| Mar 3, 2025 – Mar 7, 2025 | $8.03 | $9.29 | $6.67 | $8.94 | 0 |
| Mar 10, 2025 – Mar 14, 2025 | $8.76 | $9.62 | $7.94 | $9.61 | 0 |
| Mar 17, 2025 – Mar 21, 2025 | $9.65 | $10.08 | $7.48 | $7.62 | 0 |
| Mar 24, 2025 – Mar 28, 2025 | $7.73 | $7.88 | $6.63 | $6.87 | 0 |
| Mar 31, 2025 – Apr 4, 2025 | $6.61 | $6.86 | $5.59 | $6.10 | 0 |
| Apr 7, 2025 – Apr 11, 2025 | $5.83 | $7.39 | $5.14 | $7.37 | 0 |
| Apr 14, 2025 – Apr 17, 2025 | $7.59 | $8.92 | $7.22 | $8.78 | 0 |
| Apr 21, 2025 – Apr 25, 2025 | $8.73 | $10.50 | $8.20 | $8.39 | 0 |
| Apr 28, 2025 – May 2, 2025 | $8.35 | $9.82 | $7.93 | $8.64 | 0 |
| May 5, 2025 – May 9, 2025 | $8.54 | $9.40 | $7.79 | $8.82 | 0 |
| May 12, 2025 – May 16, 2025 | $9.00 | $9.70 | $7.99 | $8.64 | 0 |
| May 19, 2025 – May 23, 2025 | $8.51 | $9.71 | $8.48 | $9.16 | 0 |
| May 26, 2025 – May 30, 2025 | $9.34 | $9.90 | $8.79 | $9.23 | 0 |
| Jun 2, 2025 – Jun 6, 2025 | $9.29 | $11.52 | $9.25 | $11.27 | 0 |
| Jun 9, 2025 – Jun 13, 2025 | $11.52 | $12.10 | $11.10 | $11.36 | 0 |
| Jun 16, 2025 – Jun 20, 2025 | $11.46 | $11.61 | $9.82 | $10.88 | 0 |
| Jun 23, 2025 – Jun 27, 2025 | $10.88 | $11.58 | $10.41 | $10.93 | 0 |
| Jun 30, 2025 – Jul 3, 2025 | $10.91 | $11.50 | $10.60 | $11.20 | 0 |
| Jul 7, 2025 – Jul 11, 2025 | $11.15 | $11.97 | $10.75 | $11.48 | 0 |
| Jul 14, 2025 – Jul 18, 2025 | $11.44 | $12.10 | $10.63 | $10.72 | 0 |
| Jul 21, 2025 – Jul 25, 2025 | $10.73 | $13.97 | $10.54 | $13.63 | 0 |
| Jul 28, 2025 – Aug 1, 2025 | $13.73 | $16.15 | $12.95 | $15.54 | 0 |
| Aug 4, 2025 – Aug 8, 2025 | $15.59 | $17.57 | $15.04 | $16.00 | 0 |
| Aug 11, 2025 – Aug 15, 2025 | $16.00 | $19.27 | $15.64 | $18.93 | 0 |
| Aug 18, 2025 – Aug 22, 2025 | $18.93 | $19.37 | $16.02 | $17.63 | 0 |
| Aug 25, 2025 – Aug 29, 2025 | $17.60 | $17.78 | $16.37 | $17.13 | 0 |
| Sep 1, 2025 – Sep 5, 2025 | $16.86 | $21.03 | $16.66 | $19.97 | 0 |
| Sep 8, 2025 – Sep 12, 2025 | $20.08 | $20.32 | $17.02 | $17.57 | 0 |
| Sep 15, 2025 – Sep 19, 2025 | $17.83 | $18.00 | $15.55 | $16.38 | 0 |
| Sep 22, 2025 – Sep 26, 2025 | $16.40 | $17.32 | $16.00 | $17.26 | 0 |
| Sep 29, 2025 – Oct 3, 2025 | $17.23 | $19.23 | $17.06 | $18.63 | 0 |
| Oct 6, 2025 – Oct 10, 2025 | $18.72 | $20.68 | $18.18 | $19.62 | 0 |
| Oct 13, 2025 – Oct 17, 2025 | $19.79 | $22.39 | $19.56 | $20.97 | 0 |
| Oct 20, 2025 – Oct 24, 2025 | $21.37 | $23.34 | $21.02 | $21.86 | 0 |
| Oct 27, 2025 – Oct 31, 2025 | $21.97 | $26.90 | $21.89 | $25.85 | 0 |
| Nov 3, 2025 – Nov 7, 2025 | $25.92 | $26.22 | $21.98 | $22.96 | 0 |
| Nov 10, 2025 – Nov 14, 2025 | $23.52 | $25.10 | $22.59 | $24.53 | 0 |
| Nov 17, 2025 – Nov 21, 2025 | $24.39 | $26.20 | $24.10 | $25.55 | 0 |
| Nov 24, 2025 – Nov 28, 2025 | $25.35 | $33.00 | $25.32 | $28.60 | 0 |
| Dec 1, 2025 – Dec 5, 2025 | $28.32 | $29.89 | $24.61 | $27.75 | 0 |
| Dec 8, 2025 – Dec 12, 2025 | $28.03 | $29.55 | $26.78 | $27.14 | 0 |
| Dec 15, 2025 – Dec 19, 2025 | $27.56 | $30.56 | $26.03 | $29.35 | 0 |
| Dec 22, 2025 – Dec 26, 2025 | $29.29 | $30.89 | $29.00 | $29.48 | 0 |
| Dec 29, 2025 – Jan 2, 2026 | $29.48 | $29.92 | $26.72 | $27.07 | 0 |
| Jan 5, 2026 – Jan 9, 2026 | $27.07 | $30.60 | $25.00 | $29.75 | 0 |
| Jan 12, 2026 – Jan 16, 2026 | $29.73 | $33.68 | $29.34 | $31.00 | 0 |
| Jan 19, 2026 – Jan 23, 2026 | $30.22 | $32.52 | $29.08 | $30.02 | 0 |
| Jan 26, 2026 – Jan 30, 2026 | $29.77 | $32.83 | $29.61 | $31.08 | 0 |
| Feb 2, 2026 – Feb 6, 2026 | $31.10 | $32.38 | $25.87 | $26.20 | 0 |
| Feb 9, 2026 – Feb 13, 2026 | $26.24 | $28.58 | $8.52 | $8.75 | 0 |
| Feb 16, 2026 – Feb 20, 2026 | $8.69 | $9.00 | $7.93 | $8.08 | 0 |
| Feb 23, 2026 – Feb 27, 2026 | $8.09 | $8.32 | $7.62 | $7.68 | 0 |
| Mar 2, 2026 – Mar 6, 2026 | $7.51 | $8.01 | $7.25 | $7.66 | 0 |
| Mar 9, 2026 – Mar 13, 2026 | $7.65 | $9.76 | $7.64 | $9.23 | 0 |
| Mar 16, 2026 – Mar 20, 2026 | $9.29 | $9.90 | $8.16 | $8.67 | 0 |
| Mar 23, 2026 – Mar 27, 2026 | $8.71 | $10.43 | $8.10 | $8.67 | 0 |
| Mar 30, 2026 – Apr 2, 2026 | $8.53 | $9.64 | $8.29 | $9.50 | 0 |
| Apr 6, 2026 – Apr 10, 2026 | $9.49 | $10.67 | $9.31 | $10.49 | 0 |
| Apr 13, 2026 – Apr 17, 2026 | $10.45 | $10.64 | $9.68 | $9.99 | 0 |
| Apr 20, 2026 – Apr 24, 2026 | $9.98 | $10.09 | $9.06 | $9.30 | 0 |
| Apr 27, 2026 – May 1, 2026 | $9.22 | $9.65 | $8.97 | $9.40 | 0 |
| May 4, 2026 – May 8, 2026 | $9.34 | $9.57 | $8.69 | $9.09 | 0 |
| May 11, 2026 – May 15, 2026 | $9.20 | $9.60 | $8.51 | $9.09 | 0 |
| May 18, 2026 – May 22, 2026 | $8.97 | $9.13 | $7.99 | $8.37 | 0 |
| May 25, 2026 – May 29, 2026 | $8.44 | $8.55 | $8.11 | $8.36 | 0 |
| Jun 1, 2026 – Jun 5, 2026 | $8.33 | $8.64 | $6.98 | $7.05 | 0 |
| Jun 8, 2026 – Jun 12, 2026 | $7.16 | $7.16 | $5.85 | $6.10 | 0 |
| Jun 15, 2026 – Jun 18, 2026 | $6.19 | $6.52 | $5.86 | $6.25 | 0 |
| Jun 22, 2026 – Jun 26, 2026 | $6.33 | $6.78 | $6.24 | $6.75 | 0 |
| Jun 29, 2026 – Jul 2, 2026 | $6.77 | $7.72 | $6.56 | $7.51 | 0 |
| Jul 6, 2026 – Jul 10, 2026 | $7.50 | $8.00 | $7.28 | $7.53 | 0 |
| Jul 13, 2026 – Jul 17, 2026 | $7.47 | $7.53 | $6.90 | $7.01 | 0 |
| Jul 20, 2026 – Jul 24, 2026 | $6.99 | $7.15 | $6.16 | $6.41 | 0 |
| Jul 27, 2026 – Jul 31, 2026 | $6.47 | $6.69 | $6.09 | $6.31 | 0 |
| Aug 3, 2026 – Aug 7, 2026 | $6.31 | $7.26 | $6.18 | $7.25 | 0 |
| Aug 10, 2026 – Aug 14, 2026 | $7.32 | $7.70 | $6.80 | $7.07 | 0 |
| Aug 17, 2026 – Aug 21, 2026 | $7.02 | $7.56 | $6.73 | $6.97 | 0 |
| Aug 24, 2026 – Aug 28, 2026 | $7.00 | $7.31 | $6.46 | $6.69 | 0 |
| Aug 31, 2026 – Sep 4, 2026 | $6.64 | $6.98 | $5.77 | $6.01 | 0 |
Valuation
| Metric | Value | Upside |
|---|---|---|
| IC Value | $5.47 | -9% |
| P/E | -3.47 | |
| P/B | 1.46 | |
| P/S | 174.16 | |
| EV/EBITDA | -1.09 | |
| PEG | -4.41 | |
| P/TBV | 1.46 |
Valuation history
Annual price overlaid with each model's fair value. Y-axis is log scale.
| Year | Price | AI | IC | Graham-Dodd | Graham Formula |
|---|---|---|---|---|---|
| 2011 | |||||
| 2012 | |||||
| 2013 | |||||
| 2014 | |||||
| 2015 | |||||
| 2016 | |||||
| 2017 | |||||
| 2018 | |||||
| 2019 | |||||
| 2020 | |||||
| 2021 | |||||
| 2022 | |||||
| 2023 | |||||
| 2024 | $8.94 | $12.52 | |||
| 2025 | $9.23 | $9.33 |
Historic valuation ratios
Pick a category, then toggle metrics to compare.
Line items
Line items
Line items
About Upstream Bio, Inc.
Upstream Bio, Inc. is a biotechnology company in the clinical development stage, dedicated to innovating therapies for inflammatory conditions, particularly those affecting the severe respiratory system. Its pipeline notably features verekitug, a monoclonal antibody designed to selectively target and suppress the thymic stromal lymphopoietin receptor. Beyond this, the company is actively developing treatments for severe asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease. Established in 2021, Upstream Bio maintains its operational base in Waltham, Massachusetts.
- CEO
- E. Rand Sutherland
- Employees
- 75
- Beta
- 1.16
Scroll horizontally for additional metrics. Ticker column stays fixed.
| Basic Info | IC Valuation | Core Valuation | Profitability | Leverage & Liquidity | Growth | Cash Flow | Dividends | Enterprise Value | Risk | ||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ticker | Company Name | Price | Market Cap | Value | Upside | P/E | P/B | P/S | EV/EBITDA | PEG | P/TBV | Gross Margin | Operating Margin | Net Margin | ROE | ROIC | ROA | Debt/Equity | Interest Coverage | Current Ratio | Quick Ratio | Net Debt/EBITDA | EPS Growth | Sales Growth | FCF Growth | FCF Yield | Op Cash Flow Ratio | Cash ROIC | Dividend Yield | Dividend Payout | Shareholder Yield | EV/EBIT | EV/FCF | EV/Sales | Altman Z-Score |
| UPB | Upstream Bio, Inc. | $7.25 | 366.79M | $9.33 | +29% | -3.47 | 1.46 | 174.16 | -1.09 | -4.41 | 1.46 | 100.00% | -5618.82% | -5026.03% | -35.43% | -41869.71% | -34.34% | 0.00 | — | 26.15 | 25.44 | 0.70 | 78.52% | 20.42% | 123.58% | -26.85% | -9.91 | -34840.73% | 0.00% | 0.00% | 0.00% | -0.98 | -1.18 | 54.95 | 19.64 |
| AMLX | Amylyx Pharmaceuticals, I… | $21.85 | 2.43B | $1.55 | -93% | -9.14 | 4.33 | — | -7.02 | — | 4.33 | 0.00% | 0.00% | 0.00% | -61.59% | 1975.65% | -55.00% | 0.02 | — | 14.27 | 13.98 | 1.53 | -65.46% | -100.00% | -26.41% | -9.33% | -5.44 | 1591.46% | 0.00% | 0.00% | 10.98% | -6.60 | -8.20 | — | 25.39 |
| NTLA | Intellia Therapeutics, In… | $10.97 | 1.23B | $9.46 | -14% | -2.66 | 2.06 | 20.44 | -2.59 | — | 2.06 | 76.47% | -651.67% | -609.85% | -67.26% | -110.87% | -51.06% | 0.14 | — | 5.08 | 4.42 | 0.16 | -27.43% | 16.92% | 0.00% | -25.65% | -3.36 | -89.17% | 0.00% | 0.00% | 6.01% | -2.33 | -2.89 | 15.17 | -0.49 |
| NVAX | Novavax, Inc. | $7.70 | 1.27B | $30.71 | +299% | 3.77 | -12.98 | 1.48 | 2.38 | — | -6.88 | 93.67% | 50.14% | 39.19% | -117.16% | -58.11% | 32.17% | -1.95 | 24.98 | 2.13 | 1.83 | 0.02 | -306.50% | 64.69% | 149.40% | -15.08% | -0.53 | 25.92% | 0.00% | 0.00% | 0.29% | 2.08 | -4.69 | 1.04 | -1.61 |
| PHVS | Pharvaris N.V. | $33.42 | 2.34B | — | — | -7.49 | 4.79 | — | -5.83 | -37.90 | 4.79 | 0.00% | 0.00% | 0.00% | -64.45% | 1070.30% | -58.60% | 0.00 | — | 10.11 | 10.01 | 1.68 | 19.76% | — | 13.73% | -10.55% | -4.63 | 864.94% | 0.00% | 0.00% | 0.85% | -5.95 | -7.36 | — | 22.38 |
| RLAY | Relay Therapeutics, Inc. | $19.69 | 3.45B | $14.48 | -26% | -6.43 | 3.13 | 115.77 | -4.60 | — | 3.13 | 76.83% | -1971.59% | -1800.58% | -41.12% | -672.97% | -37.05% | 0.06 | — | 22.61 | 21.68 | 0.19 | -31.78% | 53.44% | -6.08% | -13.27% | -9.21 | -524.31% | 0.00% | 0.00% | 0.00% | -4.15 | -5.32 | 81.77 | 14.60 |
| SNDX | Syndax Pharmaceuticals, I… | $19.92 | 1.77B | $38.90 | +95% | -7.13 | 31.50 | 11.81 | -7.82 | — | 31.50 | 95.96% | -158.45% | -165.60% | -161.82% | -1128.98% | -45.50% | 5.36 | -8.08 | 4.40 | 4.03 | -0.84 | -11.80% | 627.84% | 17.56% | -15.87% | -2.69 | -1336.04% | 0.00% | 0.00% | 0.00% | -7.21 | -6.09 | 11.42 | -1.81 |
| SYRE | Spyre Therapeutics, Inc. | $104.35 | 9.06B | — | — | -16.46 | 3.57 | — | -8.58 | — | 3.57 | 0.00% | 0.00% | 0.00% | -25.17% | 331.08% | -22.39% | 0.00 | — | 13.25 | 12.89 | 0.41 | -37.74% | — | 7.52% | -6.62% | -2.88 | 267.42% | 0.00% | 0.00% | 0.00% | -8.58 | -10.63 | — | 22.70 |
| WVE | Wave Life Sciences Ltd. | $5.93 | 1.17B | $15.97 | +169% | -10.74 | 4.17 | 51.39 | -8.24 | -14.75 | 4.17 | 79.28% | -504.09% | -478.33% | -55.56% | 343.98% | -41.26% | 0.03 | — | 6.47 | 6.35 | 2.99 | 72.86% | -60.55% | 23.85% | -8.57% | -1.97 | 300.58% | 0.00% | 0.00% | 14.01% | -7.48 | -8.56 | 37.72 | 8.76 |
| ZBIO | Zenas BioPharma, Inc. | $31.86 | 2.01B | $13.05 | -59% | -2.85 | 4.44 | 107.53 | -2.19 | -2.29 | 4.44 | 100.00% | -2113.85% | -3777.37% | -136.22% | 723.88% | -100.25% | 0.33 | -28.85 | 5.61 | 5.48 | 0.08 | 124.47% | 100.00% | 43.86% | -16.03% | -2.75 | 590.33% | 0.00% | 0.00% | 0.00% | -3.84 | -4.71 | 81.21 | 0.88 |
Disclaimer: Information on this page is provided for educational purposes only and does not constitute investment advice. Upside computed as ($5.47 ÷ $6.01) − 1 = -8.99% (IC, example).